de Oliveira Antonio Flávio Queiroz, Arcanjo Francisco Plácido Nogueira, Rodrigues Maria Rosineida Paiva, Rosa E Silva Ana Augusta, Hall Peter Richard
Postgraduate Program in Health Sciences, Federal University of Ceará, Sobral, Brazil.
Faculty of Medicine, Federal University of Ceará, Sobral, Brazil.
J Dermatolog Treat. 2023 Dec;34(1):2138692. doi: 10.1080/09546634.2022.2138692. Epub 2022 Oct 31.
To conduct a systematic review and meta-analysis to verify the efficacy of using autologous platelet-rich plasma (PRP) in female pattern alopecia (FPA).
Androgenetic alopecia is the leading cause of hair loss in men andwomen and often impacts self-esteem and quality of life.
MEDLINE/PubMed, Cochrane Library, ClinicalTrials.gov, and EMBASE up to May 2021.
We identified all studies evaluating the effect of PRP in FPA. A narrative synthesis was performed from data on the efficacy of PRP treatment and adverse effects; quantitative results of PRP use compared to control treatment for female androgenetic alopecia (AGA) were synthesized. The outcomes analyzed were terminal density and hair thickness.
Seven articles were selected for this review. Meta-analysis showed that PRP-based interventions were able to increase terminal hair density compared to control (standardized mean difference (SMD)=2.98, 95% confidence intervals (CIs)=1.10, 4.85), with no significant increase in hair thickness (SMD = 1.16, 95% CI= -0.96, 3.28). During and after treatment, no major side effects were reported by patients or researchers.
The use of autologous PRP injections in female AGA seems to be promising, with more consistent results on terminal hair density. However, caution is recommended in the interpretation of these results until they can be replicated in larger and more representative samples. PROSPERO registration number CRD42021257154.
进行系统评价和荟萃分析，以验证自体富血小板血浆（PRP）治疗女性型脱发（FPA）的疗效。
雄激素性脱发是男性和女性脱发的主要原因，常影响自尊和生活质量。
截至2021年5月的MEDLINE/PubMed、Cochrane图书馆、ClinicalTrials.gov和EMBASE。
我们检索了所有评估PRP治疗FPA效果的研究。根据PRP治疗的疗效和不良反应数据进行叙述性综合分析；综合PRP与女性雄激素性脱发（AGA）对照治疗的定量结果。分析的结局指标为终毛密度和毛发厚度。
本综述共纳入7篇文章。荟萃分析显示，与对照组相比，基于PRP的干预措施能够增加终毛密度（标准化均数差（SMD）=2.98，95%置信区间（CI）=1.10，4.85），但毛发厚度无显著增加（SMD = 1.16，95% CI = -0.96，3.28）。在治疗期间及治疗后，患者或研究人员均未报告重大副作用。
自体PRP注射治疗女性AGA似乎前景良好，在终毛密度方面的结果更为一致。然而，在这些结果能够在更大且更具代表性的样本中得到重复验证之前，建议谨慎解读这些结果。PROSPERO注册号CRD42021257154。
