巨噬细胞相关长链非编码 RNA MALR 促进 ILF3 液-液相分离以促进食管癌中 HIF1α 信号通路。
The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid-Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer.
机构信息
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China.
Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, P.R. China.
出版信息
Cancer Res. 2023 May 2;83(9):1476-1489. doi: 10.1158/0008-5472.CAN-22-1922.
Abstract
Secretion of TNFα by tumor-associated macrophages stimulates cancer cells to upregulate lncRNA MALR, which induces ILF3 liquid-liquid phase separation and activation of HIF1α signaling to promote cancer progression.
摘要
肿瘤相关巨噬细胞分泌的 TNFα 刺激癌细胞上调 lncRNA MALR，诱导 ILF3 液-液相分离和 HIF1α 信号激活，从而促进癌症进展。
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