奥密克戎 BA.2.75 变异株的病毒学特征。

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.

机构信息

Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan; Center for Animal Disease Control, University of Miyazaki, Miyazaki, Japan.

Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

出版信息

Cell Host Microbe. 2022 Nov 9;30(11):1540-1555.e15. doi: 10.1016/j.chom.2022.10.003. Epub 2022 Oct 18.

DOI:10.1016/j.chom.2022.10.003

PMID:36272413

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9578327/

Abstract

The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency, but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5.

摘要

SARS-CoV-2 奥密克戎 BA.2.75 变异株于 2022 年 5 月出现。BA.2.75 是 BA.2 的一个分支，但与目前占主导地位的 BA.5 分支在系统发育上有明显区别。在这里，我们表明 BA.2.75 的有效繁殖数大于 BA.5，且免疫原性特征不同。我们确定了 BA.2.75 对疫苗接种者和康复者血清以及一系列临床可用的抗病毒药物和抗体的敏感性。抗病毒药物的效力在很大程度上得以保留，但抗体的敏感性取决于 BA.2.75 的几个关键特异性突变。BA.2.75 的刺突蛋白与人受体 ACE2 的结合亲和力更高。此外，BA.2.75 的融合性、在人肺泡上皮细胞中的生长效率以及在仓鼠中的内在致病性均高于 BA.2。我们的多层次研究表明，BA.2.75 获得了独立于 BA.5 的病毒学特性，BA.2.75 对全球健康的潜在风险大于 BA.5。