Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Br J Nutr. 2023 Jun 14;129(11):1888-1896. doi: 10.1017/S000711452200215X. Epub 2022 Oct 24.
Sarcopenia is more common in the elderly and causes adverse outcomes with increased morbidity and mortality. This prospective cohort study assessed the association of sarcopenia risk with the severity of COVID-19 at the time of admission and during hospitalisation and the length of hospital stay. Two hundred patients (aged ≥ 60 years) who were hospitalised for COVID-19 were enrolled using consecutive sampling between 29 December 2020 and 20 May 2021. The sarcopenia score of the patients was assessed using the Strength, Assistance in walking, Rising from a chair, Climbing stairs, and Falls questionnaire. The severity of COVID-19 was determined using the modified National Early Warning Score (m-NEWS) system for 2019 n-CoV-infected patients at admission (T1), day three (T2) and at discharge (T3). Data were analysed using SPSS, version 22 and STATA, version 14. Of the 165 patients included, thirty four (20·6 %) were at risk of sarcopenia. The length of hospital stay was slightly longer in patients with sarcopenia risk, but the difference was not significant ( = 0·600). The adjusted OR of respiratory rate (RR) > 20 /min at T1 for the sarcopenia risk group was 6·7-times higher than that for the non-sarcopenic group ( = 0·002). According to generalised estimating equations, after adjusting for confounding factors, the m-NEWS score was 5·6 units higher in patients at risk of sarcopenia ( < 0·001). Sarcopenia risk could exacerbate COVID-19 severity and increase RR at admission, as well as the need for oxygen therapy at discharge.
肌少症在老年人中更为常见，并导致发病率和死亡率增加的不良后果。这项前瞻性队列研究评估了肌少症风险与入院时和住院期间 COVID-19 严重程度以及住院时间的关系。2020 年 12 月 29 日至 2021 年 5 月 20 日，通过连续抽样，纳入了 200 名因 COVID-19 住院的患者（年龄≥60 岁）。使用 Strength、Assistance in walking、Rising from a chair、Climbing stairs 和 Falls 问卷评估患者的肌少症评分。使用改良的 2019 年 n-CoV 感染患者国家早期预警评分（m-NEWS）系统在入院时（T1）、第 3 天（T2）和出院时（T3）评估 COVID-19 的严重程度。数据使用 SPSS 版本 22 和 STATA 版本 14 进行分析。在纳入的 165 名患者中，有 34 名（20.6%）有肌少症风险。有肌少症风险的患者的住院时间略长，但差异无统计学意义（=0.600）。T1 时呼吸频率（RR）>20/min 的肌少症风险组的调整比值比（OR）是无肌少症组的 6.7 倍（=0.002）。根据广义估计方程，在校正混杂因素后，肌少症风险患者的 m-NEWS 评分高 5.6 分（<0.001）。肌少症风险可能会使 COVID-19 严重程度恶化，并增加入院时的 RR，以及出院时需要氧疗。
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