Al-Matouq Jenan Ahmed, Ali Mohammad Daud, Al-Somali Samiah Mohammad, Ahmad Ayaz, Banu Nuzhat, Patel Munfis
Department of Clinical Laboratory Sciences, Mohammed Al-Mana College for Medical Sciences, Abdulrazaq Bin Hammam Street, Al Safa, Dammam 34222, Saudi Arabia.
Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Abdulrazaq Bin Hammam Street, Al Safa, Dammam 34222, Saudi Arabia.
Infect Prev Pract. 2022 Dec;4(4):100251. doi: 10.1016/j.infpip.2022.100251. Epub 2022 Oct 15.
BACKGROUND: Reports of local and systemic side-effects of COVID-19 vaccination may play an important role in public confidence in the acceptance of the COVID-19 vaccine booster dose. METHODS: We conducted a retrospective cross-sectional study among adults living in Eastern Province of Saudi Arabia. A link to the survey was distributed to community members via WhatsApp, SMS, or e-mail. Participants' general and demographic information was also collected, as well as information about any local and systemic side-effects reported following vaccination. RESULTS: A total of 370/390 (94.87%) of respondents reported one or more side-effects. Pain or redness at the site of injection (88.92%), fatigue (43.78%), body pain fever (37.84%), and headache (15.95%) were the most commonly reported side-effects. Moreover, 2.43% of the participants reported side-effects needed to see a physician; only four were admitted to the hospital. The non-healthcare respondents (n=273 (97.15%), OR (95% CI) = 5.22 (2.02, 13.48, <0.001) were more likely to report side-effects compared to the healthcare related respondents (n=36 (85.71%), OR (95% CI) = 0.25 (0.10, 0.70), =0.013). CONCLUSION: According to this study, the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine was safe when given to Saudi Arabian adults. All reported side-effects were mild to moderate. The findings will likely persuade vaccine-hesitant individuals and pessimists to accept booster dose of COVID-19 vaccine.
背景：关于新冠疫苗接种的局部和全身副作用的报告，可能在公众对接受新冠疫苗加强针的信心方面发挥重要作用。 方法：我们在沙特阿拉伯东部省份的成年人中开展了一项回顾性横断面研究。通过WhatsApp、短信或电子邮件向社区成员分发了调查问卷链接。还收集了参与者的一般和人口统计学信息，以及接种疫苗后报告的任何局部和全身副作用的信息。 结果：共有370/390（94.87%）的受访者报告了一种或多种副作用。注射部位疼痛或发红（88.92%）、疲劳（43.78%）、身体疼痛发热（37.84%）和头痛（15.95%）是最常报告的副作用。此外，2.43%的参与者报告副作用需要看医生；只有4人住院。与医疗相关受访者（n = 36（85.71%），OR（95%CI）= 0.25（0.10，0.70），P = 0.013）相比，非医疗受访者（n = 273（97.15%），OR（95%CI）= 5.22（2.02，13.48），P < 0.001）更有可能报告副作用。 结论：根据本研究，辉瑞 - 生物科技（BNT162b2）新冠疫苗在沙特阿拉伯成年人中接种时是安全的。所有报告的副作用均为轻至中度。这些发现可能会说服对疫苗持犹豫态度的人和悲观者接受新冠疫苗加强针。
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