Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou 310015, China.
Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.
Sci Total Environ. 2023 Jan 20;857(Pt 3):159656. doi: 10.1016/j.scitotenv.2022.159656. Epub 2022 Oct 22.
As a special category of pesticides, chiral pesticides have increased the difficulty in investigating pesticide toxicity. Based on their usage, chiral pesticides can be divided into insecticides, herbicides, and fungicides. Over the past decades, great efforts have been made on elucidating their toxicological effects. However, no literature has reviewed the enantioselective toxicity of chiral pesticides since 2014. In recent years, more chiral pesticides have been registered for application. As such, huge research progresses have been achieved in enantioselective toxicity of chiral pesticides. Generally, more researches have remedied the knowledge gap in toxicological effects of old and new chiral pesticides. And the toxicological endpoints being evaluated have become more specific rather than centering on basic toxicity and target organisms. Besides, the underlying mechanisms accounting for the enantioselectivity in toxicological effects of chiral pesticides have been discussed as well. All in all, this review provides the critical knowledge for risk assessments, and help to drive the green-technology of single- or enriched-enantiomer pesticides and formulation of relevant laws and regulations.
作为特殊的农药类别，手性农药增加了调查农药毒性的难度。基于其用途，手性农药可以分为杀虫剂、除草剂和杀菌剂。在过去的几十年中，人们在阐明其毒理学效应方面做出了巨大的努力。然而，自 2014 年以来，没有文献综述过手性农药的对映选择性毒性。近年来，更多的手性农药被注册用于应用。因此，在手性农药的对映选择性毒性方面取得了巨大的研究进展。通常，更多的研究弥补了新旧手性农药毒理学效应知识空白。并且，评价的毒理学终点变得更加具体，而不是集中在基本毒性和靶标生物上。此外，还讨论了手性农药毒理学效应中对映选择性的潜在机制。总之，这篇综述为风险评估提供了关键知识，有助于推动单一或富集对映异构体农药的绿色技术以及相关法律法规的制定。
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