Giles T D, Sander G E, Rice J C, Quiroz A C
Peptides. 1987 Jul-Aug;8(4):609-12. doi: 10.1016/0196-9781(87)90033-7.
The cardiovascular effects of bolus doses of methionine-enkephalin (Met5-ENK) (1 to 100 micrograms/kg) were studied in 9 subjects in whom, at cardiac catheterization for evaluation of chest pain, patent coronary arteries were found. Met5-ENK produced a simultaneous increase in blood pressure and heart rate beginning within 20 sec, reaching maximal values between 30 and 40 sec, and then terminating by 60 sec. Heart rate, systolic, diastolic, and mean arterial blood pressures increased significantly (p less than 0.0005); pulse pressure remained unchanged. Positive dose-effect relationships were observed for heart rate (p less than 0.002), systolic, diastolic, and mean arterial blood pressures (p less than 0.05). Naloxone (0.5 mg/kg), given to 4 subjects, prevented the heart rate and blood pressure changes associated with Met5-ENK administration, demonstrating that the cardiovascular changes were mediated by opiate receptors. Subjects also described cutaneous paresthesias which were not prevented by naloxone pretreatment. These data suggest a role for peripheral enkephalins in cardiovascular regulation.
在9名因胸痛行心导管检查且冠状动脉通畅的受试者中，研究了大剂量甲硫氨酸脑啡肽（Met5-ENK）（1至100微克/千克）的心血管效应。Met5-ENK在20秒内使血压和心率同时升高，30至40秒达到最大值，然后在60秒内恢复至初始水平。心率、收缩压、舒张压和平均动脉压显著升高（p<0.0005）；脉压保持不变。心率（p<0.002）、收缩压、舒张压和平均动脉压（p<0.05）呈正剂量效应关系。给4名受试者注射纳洛酮（0.5毫克/千克）可预防与Met5-ENK给药相关的心率和血压变化，表明心血管变化是由阿片受体介导的。受试者还描述了皮肤感觉异常，纳洛酮预处理不能预防这种异常。这些数据表明外周脑啡肽在心血管调节中起作用。
