Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Division of Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Medicine (Baltimore). 2022 Oct 21;101(42):e31035. doi: 10.1097/MD.0000000000031035.
The purpose of our study was to evaluate the effectiveness of low-to moderate intensity aerobic training on cardiorespiratory functions in chronic unconditioned stroke patients. The oxygen uptake efficiency slope (OUES) and the ventilatory threshold (VO2-VT) could represent the aerobic capacity in submaximal test. Our study examined the application of the submaximal parameters for evaluating aerobic capacity of chronic stroke patients.
In our assessor-blinded controlled pilot study 37 patients were randomized into 2 groups named: intervention group (IG, n: 21) and control group (CG, n:16), respectively. Cardiorespiratory functions were evaluated by ergospirometer before and after the 4-week (20 days) program. Both groups participated in daily occupational therapy (30 minutes) and conventional, customized physiotherapy CG (60 minutes), IG (30 minutes). Only IG performed aerobic training by bicycles (30 minutes) aiming to reach low-to moderate training intensity. Outcome measures included peak oxygen uptake (VO2 peak), OUES, VO2-VT, functional exercise capacity 6-Minute Walking Test (6MWT) and Functional Independence Measure.
Thirty-five subjects completed the study. The VO2 peak uptake was very low in both groups (IG: 11.9 mL/kg/min, CG: 12.45 mL/kg/min) and did not improve after the program, but submaximal parameters such as VO2-VT (P < .01) and OUES (P < .001) have shown significant improvement, but only in IG regardless of insufficient impact on VO2 peak. Each participant in both groups was unable to permanently reach the moderate intensity zone. Functional Independence Measure changed for the better in both groups, but 6MWT only in the IG.
Four-week exercise training even at low intensity by lower limb cycle ergometer may provide benefit on aerobic and functional capacity without improvement of VO2 peak on unconditioned chronic stroke patients.
本研究旨在评估低至中等强度的有氧运动对慢性非条件性中风患者心肺功能的有效性。摄氧量效率斜率（OUES）和通气阈值（VO2-VT）可以代表亚极量测试中的有氧能力。我们的研究检验了亚极量参数在评估慢性中风患者有氧能力中的应用。
在我们的评估者盲法对照性初步研究中，将 37 名患者随机分为两组，分别命名为干预组（IG，n=21）和对照组（CG，n=16）。心肺功能在 4 周（20 天）的项目前后通过测功计进行评估。两组均参加日常职业治疗（30 分钟）和常规的、定制的 CG 物理治疗（60 分钟），IG（30 分钟）。仅 IG 通过自行车进行有氧运动（30 分钟），以达到低至中等的训练强度。主要结局指标包括峰值摄氧量（VO2 峰值）、OUES、VO2-VT、6 分钟步行测试（6MWT）和功能独立性测量。
35 名受试者完成了研究。两组的 VO2 峰值摄取量都非常低（IG：11.9ml/kg/min，CG：12.45ml/kg/min），项目后并未改善，但亚极量参数，如 VO2-VT（P<0.01）和 OUES（P<0.001）有显著改善，但仅在 IG 中，尽管对 VO2 峰值的影响不足。两组中的每个参与者都无法永久达到中等强度区。两组的功能独立性测量均有改善，但 IG 中的 6MWT 仅改善。
即使在慢性非条件性中风患者中，通过下肢功率车进行 4 周的低强度运动训练，也可能对有氧和功能能力有益，而不会改善 VO2 峰值。
