PURPOSE OF REVIEW: Transcatheter valve therapies for mitral and tricuspid regurgitation are alternative methods to more invasive surgical treatment in candidates with high or prohibitive surgical risk. Echocardiography is the primary imaging modality for patient selection, pre-procedural planning, intra-procedural guidance, and post-procedural follow-up. RECENT FINDINGS: This article outlines the applications of transcatheter valve repair therapy for mitral and tricuspid regurgitation based on the current cardiovascular guidelines and a growing body of evidence. In this review, we provide a stepwise approach echocardiography in the guidance of the MitraClip device as currently the only FDA-approved transcatheter edge-to-edge repair device.