College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
Int J Biol Macromol. 2023 Jan 1;224:848-857. doi: 10.1016/j.ijbiomac.2022.10.171. Epub 2022 Oct 22.
Using nanocarriers to load antimicrobial agent instead of direct incorporating into film matrix could avoid burst release. Halloysite nanotubes (HNTs) are natural clays with a unique tubular structure; therefore in many studies it served as carriers to achieve a controlled release of active agents. However, when HNTs biocomposites were loaded into packaging film, the antimicrobial activity was reduced too seriously to preserve the packaged food. This study aimed to improving preservation properties of the fabricated films from two perspectives: enlarging the loading capacity of the carrier, and increasing the concentration of HNTs biocomposites. Brunauer, Emmett, Teller's test (BET) and thermogravimetric analysis (TGA) were conducted to evaluate the performance of acid treated nanocomposites. Results showed that acid treatment expanded the lumen of HNTs, increasing the loading capacity of cinnamaldehyde (Cin) from 14.6 wt% to 25.0 wt%. Active packaging films were then fabricated by incorporating Cin loaded HNTs into poly(lactic acid) matrix, and it revealed bionanocomposites at 30 wt% achieved the optimum film, considering the mechanical performance and controlled release of Cin. Cumulative release rate of the films were further verified by the fumigant antimicrobial activity. This study demonstrates a solution for improving the antimicrobial properties of packaging film without comprising mechanical strength.
使用纳米载体来负载抗菌剂，而不是直接掺入膜基质中，可以避免药物的突释。海泡石纳米管（HNTs）是一种具有独特管状结构的天然粘土，因此在许多研究中，它被用作载体，以实现活性药物的控制释放。然而，当 HNTs 生物复合材料被加载到包装膜中时，其抗菌活性会严重降低，从而无法保存包装食品。本研究旨在从两个方面提高所制备薄膜的保存性能：扩大载体的负载能力和提高 HNTs 生物复合材料的浓度。通过 Brunauer、Emmett、Teller 测试（BET）和热重分析（TGA）来评估酸处理纳米复合材料的性能。结果表明，酸处理扩大了 HNTs 的内腔，使肉桂醛（Cin）的负载量从 14.6wt%增加到 25.0wt%。然后将负载 Cin 的 HNTs 掺入聚乳酸基质中制备活性包装膜，考虑到机械性能和 Cin 的控制释放，当生物纳米复合材料达到 30wt%时，可获得最佳的薄膜。通过熏蒸抗菌活性进一步验证了薄膜的累积释放率。本研究证明了一种在不影响机械强度的情况下提高包装膜抗菌性能的解决方案。
