Department of Surgery, Yokohama City University, Yokohama, Japan;
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa, Japan.
Anticancer Res. 2022 Nov;42(11):5167-5180. doi: 10.21873/anticanres.16023.
The standard treatment for gastric cancer is surgical resection and perioperative adjuvant treatment. Multidisciplinary treatment for gastric cancer leads to nutritional and inflammatory changes. Nutritional and inflammatory changes during multidisciplinary treatment can lead to poor physical activity, severe toxicity in patients receiving chemotherapy or radiation therapy, and poor oncological outcomes. Evaluation of the perioperative nutritional and inflammatory status during treatment is necessary in order to utilize and optimize multidisciplinary therapy for gastric cancer. If physicians were able to detect the perioperative nutritional and inflammatory status before and during gastric cancer treatment, they would be able to select the optimal treatment and perioperative nutritional treatment. Recently, various types of nutrition and inflammation assessment tools were developed and reported for gastric cancer. These nutrition and inflammation assessment tools have some clinical advantages, such as ease of implementation, perioperative accessibility, and low cost. On the other hand, each tool has its own clinical characteristics, which must be understood before using it in the clinical practice. This review summarizes the background, current status, and future perspectives on the application of nutrition and inflammation assessment tools in gastric cancer treatment.
胃癌的标准治疗方法是手术切除和围手术期辅助治疗。胃癌的多学科治疗会导致营养和炎症变化。多学科治疗期间的营养和炎症变化可导致患者体力活动减少,接受化疗或放疗的患者毒性严重,以及肿瘤学结局较差。为了利用和优化胃癌的多学科治疗,有必要评估治疗期间围手术期的营养和炎症状况。如果医生能够在胃癌治疗前后检测到围手术期的营养和炎症状况,他们就能选择最佳的治疗和围手术期营养治疗。最近,已经开发并报道了各种类型的营养和炎症评估工具用于胃癌。这些营养和炎症评估工具具有一些临床优势,例如易于实施、围手术期可及性和低成本。另一方面,每种工具都有其自身的临床特点,在临床实践中使用前必须了解这些特点。这篇综述总结了营养和炎症评估工具在胃癌治疗中的应用的背景、现状和未来展望。