Yu Tengfei, Wang Rong, Ye Xun, Zeng Chun, Chen Xiaolin, Zhao Yuanli
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 West Nansihuan Road, Fengtai District, Beijing 100070, China.
Department of Neurosurgery, Peking University International Hospital, No. 1 Life Park Road, Life Science Park of Zhongguancun, Changping District, Beijing 102206, China.
Brain Sci. 2022 Sep 20;12(10):1270. doi: 10.3390/brainsci12101270.
To investigate the angioarchitectural factors associated with postoperative cerebral infarction in ischemic moyamoya disease.
Data on patients who underwent surgery for ischemic MMD from 1 October 2015 to 31 October 2020, at Peking University International Hospital were collected and retrospectively analyzed. General conditions such as patient sex, age, site of surgery, preoperative manifestations such as TIA attack and old cerebral infarction, and seven angioarchitectural factors of the MMD based on DSA were selected and measured. Statistical analysis was performed by the Pearson chi-square statistic, analysis of variance (ANOVA), and multifactor logistic regression analysis.
Age (OR, 0.969; 95%CI, 0.939-1.000; = 0.049), A1stenosis (OR, 5.843; 95%CI, 1.730-19.732; = 0.004), M1stenosis (OR, 6.206; 95%CI, 2.079-18.526; = 0.001), PCA anomalies (OR, 4.367; 95%CI, 1.452-13.129; = 0.049), Unstable compensation (OR, 5.335; 95%CI, 1.427-19.948; = 0.013), TIA (OR, 4.264; 95%CI, 1.844-9.863; = 0.001), Old cerebral infarction (OR, 2.972; 95%CI, 1.194-7.397; = 0.019). The above seven factors can be used in the regression equation to predict the probability of postoperative cerebral infarction. The prediction accuracy is 90.2%.
Age, TIA attack, old cerebral infarction, and five angioarchitectural factors of MMD are strongly associated with postoperative cerebral infarction. Seven factors, including age, TIA attack, old infarction, and four angioarchitectural factors, can be taken to quantify the probability of surgical cerebral infarction in MMD.
探讨缺血性烟雾病术后脑梗死相关的血管构筑学因素。
收集2015年10月1日至2020年10月31日在北京大学国际医院接受缺血性烟雾病手术患者的数据，并进行回顾性分析。选取患者性别、年龄、手术部位、术前表现如短暂性脑缺血发作（TIA）和陈旧性脑梗死等一般情况，以及基于数字减影血管造影（DSA）的烟雾病七个血管构筑学因素并进行测量。采用Pearson卡方检验、方差分析（ANOVA）和多因素逻辑回归分析进行统计学分析。
年龄（比值比[OR]，0.969；95%置信区间[CI]，0.939 - 1.000；P = 0.049）、大脑前动脉A1段狭窄（OR，5.843；95%CI，1.730 - 19.732；P = 0.004）、大脑中动脉M1段狭窄（OR，6.206；95%CI，2.079 - 18.526；P = 0.001）、大脑后动脉异常（OR，4.367；95%CI，1.452 - 13.129；P = 0.049）、代偿不稳定（OR，5.335；95%CI，1.427 - 19.948；P = 0.013）、TIA（OR，4.264；95%CI，1.844 - 9.863；P = 0.001）、陈旧性脑梗死（OR，2.972；95%CI，1.194 - 7.397；P = 0.019）。上述七个因素可用于回归方程预测术后脑梗死的概率。预测准确率为90.2%。
年龄、TIA发作、陈旧性脑梗死以及烟雾病的五个血管构筑学因素与术后脑梗死密切相关。包括年龄、TIA发作、陈旧性梗死和四个血管构筑学因素在内的七个因素可用于量化烟雾病手术后脑梗死的概率。
