Cetin Benhur Sirvan, Orman Ayşen
Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri 38039, Turkey.
Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin 33110, Turkey.
Children (Basel). 2022 Oct 16;9(10):1566. doi: 10.3390/children9101566.
complex (BCC) is a rare cause of sepsis in neonates, but infections are usually severe. It can be encountered unexpectedly when adequate health care is not provided. In this study, 49 neonatal cases with blood culture-proven BCC bacteremia within the first 72 h following admission to the neonatal intensive care unit between June 2017 and December 2018 were retrospectively analyzed in detail. All but one of the cases were born in Jarabulus, Al Bab, or Aleppo in Syria and were referred to Turkey due to urgent medical treatment needs. The rate of BCC bacteremia among the neonates transferred from across the border was 16.1% (48/297). The most common coexisting problems in the cases were multiple congenital malformations (12.2%), gastrointestinal system atresia (8.2%), and congenital heart diseases (4.1%). The median age at the time of their admission in Turkey was three days, and the median length of stay in another center before the referral was 11.5 h. The case fatality rate was 14.3%. In this study, a high rate of BCC infection and associated mortality was seen in neonates referred from cross-border regions. For centers accepting cases from conflict-affected regions, it is crucial to be careful regarding early detection of bacteremia, planning appropriate treatments, and preventing cross-contamination risks within the unit.
复杂（BCC）是新生儿败血症的罕见病因，但感染通常较为严重。在未提供充分医疗保健的情况下，可能会意外遇到这种情况。在本研究中，对2017年6月至2018年12月期间入住新生儿重症监护病房后72小时内血培养确诊为BCC菌血症的49例新生儿病例进行了详细的回顾性分析。除1例病例外，所有病例均出生于叙利亚的贾拉布卢斯、阿尔巴布或阿勒颇，并因紧急医疗需求转诊至土耳其。从边境地区转诊来的新生儿中BCC菌血症的发生率为16.1%（48/297）。这些病例中最常见的并存问题是多发先天性畸形（12.2%）、胃肠道闭锁（8.2%）和先天性心脏病（4.1%）。他们入住土耳其时的中位年龄为3天，转诊前在另一家中心的中位住院时间为11.5小时。病死率为14.3%。在本研究中，从跨境地区转诊来的新生儿中BCC感染率和相关死亡率较高。对于接收受冲突影响地区病例的中心而言，在早期发现菌血症、规划适当治疗以及预防病房内交叉污染风险方面保持谨慎至关重要。
