Beijing Key Laboratory of New Technology in Agricultural Application, National Demonstration Center for Experimental Plant Production Education, College of Plant Science and Technology, Beijing University of Agriculture, Beijing 102206, China.
State Key Laboratory of Agricultural Microbiology and Provincial Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Biomolecules. 2022 Oct 4;12(10):1424. doi: 10.3390/biom12101424.
In eukaryotic cells, a large number of proteins are modified by ubiquitination, which leads to proteasomal degradation or change in protein function. The protein ubiquitination process can be reversed by a process called deubiquitination, which plays an important regulatory mechanism in cellular control. Deubiquitination is catalyzed by deubiquitinating enzymes (DUBs); the cysteine proteases specifically cleave off ubiquitin from ubiquitinated substrates or ubiquitin precursors. Over the past two decades, components of different DUB families have been found to play important roles in both human and plant pathogenic fungi. Given the importance of DUBs for fungal development and virulence, in this review, we concentrate on recent findings and new insights into the roles of DUBs in different fungal pathogens, with a focus on infection-related morphogenesis and virulence, as well as their roles in development and stress response. We also summarize the DUBs-mediated regulatory mechanisms during the above processes. These findings should allow us to develop novel inhibitors to control fungal pathogens.
在真核细胞中，大量蛋白质被泛素化修饰，导致蛋白酶体降解或蛋白质功能改变。蛋白质泛素化过程可以通过一种称为去泛素化的过程逆转，该过程在细胞控制中发挥着重要的调节机制。去泛素化是由去泛素化酶（DUB）催化的；半胱氨酸蛋白酶特异性地从泛素化底物或泛素前体上切割掉泛素。在过去的二十年中，不同 DUB 家族的成分被发现分别在人和植物病原真菌中发挥着重要作用。鉴于 DUB 对真菌发育和毒力的重要性，在本综述中，我们集中讨论了 DUB 在不同真菌病原体中的作用的最新发现和新见解，重点关注与感染相关的形态发生和毒力，以及它们在发育和应激反应中的作用。我们还总结了 DUB 在上述过程中的介导的调节机制。这些发现应该使我们能够开发新型抑制剂来控制真菌病原体。
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