Zhang Man, Jin Hongyu, Cao Jiazhi, Ren Ruyu, Jia Menglu, Yang Yi, Li Xinyi, Chen Ming, Li Shen, Huang Libin, Ling Wenwu
West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Diagnostics (Basel). 2022 Sep 29;12(10):2373. doi: 10.3390/diagnostics12102373.
Portal hypertension is a common manifestation in late-to-end-stage liver diseases and can cause severe complications such as ascites, hepatic encephalopathy, etc. However, an early diagnosis of portal hypertension is often difficult as it can be asymptomatic. Though the gold standard to diagnose portal hypertension is hepatic vein catheterization, ultrasound elastography is regarded as a noninvasive alternative that can be used to accurately predict portal hypertension and a few further complications such as gastro-esophageal varices. Since ultrasound elastography is available in most medical centers, and is cheaper and noninvasive, studying its function in predicting portal hypertension is of paramount importance. Therefore, this review generalized the results of recently published articles in order to establish the indicators that were related to diagnostic and prediction efficiency. Our study found that various technologies of ultrasound elastography could be used to predict portal hypertension with satisfactory diagnostic sensitivity, specificity, accuracy, and AUC. Meanwhile, we also recognized similar diagnostic efficiency of ultrasound elastography in gastro-esophageal varices.
门静脉高压是晚期至终末期肝病的常见表现,可导致腹水、肝性脑病等严重并发症。然而,门静脉高压早期诊断往往困难,因为它可能没有症状。虽然诊断门静脉高压的金标准是肝静脉插管,但超声弹性成像被认为是一种无创替代方法,可用于准确预测门静脉高压以及一些其他并发症,如胃食管静脉曲张。由于大多数医疗中心都有超声弹性成像设备,且其价格低廉且无创,因此研究其在预测门静脉高压方面的作用至关重要。因此,本综述总结了最近发表文章的结果,以确定与诊断和预测效率相关的指标。我们的研究发现,各种超声弹性成像技术可用于预测门静脉高压,具有令人满意的诊断敏感性、特异性、准确性和曲线下面积。同时,我们也认识到超声弹性成像在胃食管静脉曲张方面具有相似的诊断效率。