Commesso Emily A, Osazuwa-Peters Nosayaha, Frank-Ito Dennis O, Einhorn Lisa, Ji Keven S Y, Greene Nathaniel H, Eapen Rose J, Raynor Eileen M
Duke University School of Medicine, Department of Head and Neck Surgery & Communication Sciences, Durham, NC, 27710, USA.
Duke University School of Medicine, Department of Anesthesiology, Division of Pediatrics, Durham, NC, 27710, USA.
Int J Pediatr Otorhinolaryngol. 2022 Dec;163:111337. doi: 10.1016/j.ijporl.2022.111337. Epub 2022 Oct 8.
The U.S. is in an opioid epidemic with greater than 40,000 deaths annually. Pediatric adenotonsillectomy is one of the most common and painful otolaryngology surgeries performed, often associated with opioid prescriptions.
To understand postoperative prescribing practices of adenotonsillectomy in a tertiary care institution and associated postoperative emergency department (ED) visits.
Descriptive analysis of retrospective cohort data.
Tertiary academic healthcare institution.
Pediatric patients <18yo undergoing adenotonsillectomy between 2013 and 2016.
INTERVENTIONS/EXPOSURES: Postoperative analgesic regimens assessed including opioid and non-opioid analgesic prescriptions upon discharge from tonsillectomy surgery.
Main outcomes included ED presentation within 30-days of surgery and reoperation. Secondary outcomes included reason for ED presentation and relation to prescribed analgesics. Data was analyzed between November 2021-February 2022.
200 patients were included in the study with 69% prescribed opioids, and 51% prescribed non-opioid analgesics. Number of opioid doses ranged widely with a median of 37 (Q1, Q3: 0, 62). There were no demographic differences in patients prescribed opioids from those who were not. Of those patients who presented to the ED, 81% were not specifically prescribed acetaminophen (p < 0.001). Regression analysis models were not predictive of postoperative analgesic regimen or 30-day ED presentation (p > 0.05) CONCLUSIONS: Wide ranges of post tonsillectomy prescribing practices currently exist in our institution. Prescribing acetaminophen may help to reduce 30-day ED presentation rate. Larger prospective studies are needed to optimize pain control regimens and reduce variability of opioid prescribing practices. Standardization of postoperative pain medication doses may also reduce postoperative ED presentations.
美国正处于阿片类药物流行之中,每年有超过40000人死亡。小儿腺样体扁桃体切除术是最常见且疼痛的耳鼻喉科手术之一,常与阿片类药物处方相关。
了解三级医疗机构中腺样体扁桃体切除术后的处方习惯以及相关的术后急诊科就诊情况。
对回顾性队列数据进行描述性分析。
三级学术医疗机构。
2013年至2016年间接受腺样体扁桃体切除术的18岁以下儿科患者。
干预措施/暴露因素:评估术后镇痛方案,包括扁桃体切除术后出院时的阿片类和非阿片类镇痛药物处方。
主要结局包括术后30天内的急诊科就诊和再次手术。次要结局包括急诊科就诊原因以及与所开镇痛药物的关系。数据于2021年11月至2022年2月进行分析。
200名患者纳入研究,69%的患者开具了阿片类药物,51%的患者开具了非阿片类镇痛药物。阿片类药物剂量范围广泛,中位数为37(第一四分位数,第三四分位数:0,62)。开具阿片类药物的患者与未开具的患者在人口统计学上无差异。在那些到急诊科就诊的患者中,81%未被专门开具对乙酰氨基酚(p<0.001)。回归分析模型无法预测术后镇痛方案或术后30天的急诊科就诊情况(p>0.05)。结论:目前我们机构中扁桃体切除术后的处方习惯差异很大。开具对乙酰氨基酚可能有助于降低术后30天的急诊科就诊率。需要开展更大规模的前瞻性研究来优化疼痛控制方案并减少阿片类药物处方习惯的变异性。术后疼痛药物剂量的标准化也可能减少术后急诊科就诊情况。