犬下颌骨中，4mm近中骨下袋缺损的愈合模式与牙种植体旁2mm缺损的愈合模式无显著差异。

The healing pattern of a 4 mm proximal infrabony defect was not significantly different from a 2 mm defect adjacent to dental implant in a canine mandible.

作者信息

An Min Kuk, Kim Hyun Ju, Choi Jin Uk, Kim Kyoung-Hwa, Lee Yong-Moo, Rhyu In-Chul, Seol Yang-Jo

机构信息

Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Department of Periodontics, Seoul National University Dental Hospital, Seoul, Korea.

出版信息

J Periodontal Implant Sci. 2022 Oct;52(5):422-434. doi: 10.5051/jpis.2106420321.

DOI:10.5051/jpis.2106420321

PMID:36302648

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9614175/

Abstract

PURPOSE

The purpose of this study was to evaluate and compare the healing patterns of 2-mm and 4-mm proximal infrabony defects adjacent to dental implants in canine mandibles.

METHODS

Four male beagles were used. Two groups were created: a 2-mm group (n=4) and a 4-mm group (n=4) depending on the horizontal dimension of proximal infrabony defects adjacent to implants. Bone healing patterns between the 2 groups were evaluated and compared at 8 and 16 weeks using radiographic, histological, histomorphometric, and fluorescent labelling analyses.

RESULTS

According to microcomputed tomography, the median bone volume fraction, bone mineral density, and the percentage of radiographic distance from the defect bottom to the most coronal bone-to-implant contact (radio-mcBIC) were 32.9%, 0.6 g/cm, and 73.7% (8 weeks) and 45.7%, 0.7 g/cm, and 76.0% (16 weeks) in the 2-mm group and 57.7%, 0.8 g/cm, and 75.7% (8 weeks) and 50.9%, 0.8 g/cm, and 74.7% (16 weeks) in the 4-mm group, respectively. According to histomorphometry, the median bone area fraction, mcBIC and the percentage of BIC amounted to 36.7%, 3.4 mm, and 58.4% (8 weeks) and 49.2%, 3.4 mm, and 70.2% (16 weeks) in the 2-mm group and 50.0%, 3.0 mm, and 64.8% (8 weeks) and 55.7%, 3.0 mm, and 69.6% (16 weeks) in the 4-mm group, respectively. No statistically significant differences were found between the groups for any variables (>0.05).

CONCLUSIONS

The proximal defects that measured 2 mm and 4 mm showed similar healing patterns at 8 and 16 weeks, and the top of bone formation in the defects was substantially limited to a maximum of 1.6 mm below the implant shoulder in both groups.

摘要

目的

本研究旨在评估和比较犬下颌骨中与牙种植体相邻的2毫米和4毫米近中骨下袋状缺损的愈合模式。

方法

使用4只雄性比格犬。根据种植体相邻近中骨下袋状缺损的水平尺寸创建两组：2毫米组（n = 4）和4毫米组（n = 4）。在第8周和第16周，使用影像学、组织学、组织形态计量学和荧光标记分析对两组之间的骨愈合模式进行评估和比较。

结果

根据微型计算机断层扫描，2毫米组在第8周时的中位骨体积分数、骨矿物质密度以及从缺损底部到最冠方骨与种植体接触处的影像学距离百分比（影像学测量的骨-种植体接触率，radio-mcBIC）分别为32.9%、0.6 g/cm和73.7%，在第16周时分别为45.7%、0.7 g/cm和76.0%；4毫米组在第8周时分别为57.7%、0.8 g/cm和75.7%，在第16周时分别为50.9%、0.8 g/cm和74.7%。根据组织形态计量学，2毫米组在第8周时的中位骨面积分数、骨-种植体接触率（mcBIC）和骨结合率（BIC）百分比分别为36.7%、3.4毫米和58.4%，在第16周时分别为49.2%、3.4毫米和70.2%；4毫米组在第8周时分别为50.0%、3.0毫米和64.8%，在第16周时分别为55.7%、3.0毫米和69.6%。两组之间在任何变量上均未发现统计学显著差异（>0.05）。