Emergency department, Clinical Hospital Sveti Duh, Zagreb, Croatia.
Department of Clinical Immunology and Rheumatology, Clinical Hospital Sveti Duh, Zagreb, Croatia.
Acta Clin Croat. 2022 Jun;61(Suppl 1):88-92. doi: 10.20471/acc.2022.61.s1.15.
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome (DIHS), is an under-recognized and potentially life-threatening hypersensitivity reaction associated with a variety of medications, many of them anti-epileptics. Patients with DRESS syndrome typically present with rash, swelling, fever, and systemic manifestations. We report a case of a patient admitted to out hospital after the administration of an anticonvulsive drug lamotrigine. She was presented with high fever, rash, face oedema and elevated liver enzymes. At admission, all previous medications were discontinued, systemic corticosteroid therapy was administered, and the patient was monitored for signs of clinical recovery. This case report suggests that in patients presenting with skin rash and systemic abnormalities after a recent change in medications, physicians should consider DRESS syndrome as a possible diagnosis and switch to a more aggressive therapy if removal of the offending agent does not result in clinical improvement. Early diagnosis can reduce the risk of complications and the mortality rate.
药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征，也称为药物诱导的超敏反应综合征（DIHS），是一种未被充分认识的潜在致命性超敏反应，与多种药物相关，其中许多是抗癫痫药。DRESS 综合征患者通常表现为皮疹、肿胀、发热和全身表现。我们报告了一例在给予抗癫痫药物拉莫三嗪后入住我院的患者。她表现为高热、皮疹、面部水肿和肝酶升高。入院时，停用了所有先前的药物，给予全身皮质类固醇治疗，并监测患者的临床恢复迹象。本病例报告表明，对于最近药物改变后出现皮疹和全身异常的患者，如果去除致病药物不能改善临床症状，医生应考虑 DRESS 综合征作为可能的诊断，并采取更积极的治疗方法。早期诊断可以降低并发症和死亡率的风险。
