Schäffer J, Panning B, Renella R, Böhme U, Piepenbrock S
Anasth Intensivther Notfallmed. 1987 Jun;22(3):145-8.
This is a report on a patient who suffered subarachnoid haemorrhage from an aneurysm of the a. cerebri media during the 28th week of pregnancy. The aneurysm was clipped under neuroleptanalgesia. Besides monitoring of heart rate, blood pressure and central venous pressure as well as the treatment parameters including end-expiratory CO2, the foetal heart rate was deduced by Doppler sonography. She was hyperventilated intraoperatively with a paCO2 of 3.8-4.1 kPa. During the actual aneurysm surgery, artificial hypotension by 20 mmHg to b.p. values around 100/160 mmHg was initiated by means of nitroglycerin. It is evident from the literature compiled on this occasion that it is mandatory to monitor foetal heart rate during controlled hypotension in pregnancy. Sodium nitroprusside should not be used to initiate artificial hypotension during pregnancy, since it may result in toxic cyanide levels in the foetus. As usual in neurosurgery, hyperventilation can be performed also during pregnancy, since placental blood flow decreases only if the CO2 concentration drops to a very low level.
这是一份关于一名患者的报告,该患者在妊娠第28周时因大脑中动脉瘤导致蛛网膜下腔出血。动脉瘤在神经安定镇痛下进行夹闭。除了监测心率、血压和中心静脉压以及包括呼气末二氧化碳在内的治疗参数外,还通过多普勒超声检查推断胎儿心率。术中她进行了过度通气,动脉血二氧化碳分压为3.8 - 4.1千帕。在实际的动脉瘤手术中,通过硝酸甘油使血压人工降低20毫米汞柱至约100/160毫米汞柱的血压值。从此次汇编的文献中可以明显看出,在妊娠期间控制性低血压时监测胎儿心率是必要的。妊娠期间不应使用硝普钠来引发人工低血压,因为它可能导致胎儿体内氰化物中毒水平升高。与神经外科手术中的常规情况一样,妊娠期间也可以进行过度通气,因为只有当二氧化碳浓度降至非常低的水平时,胎盘血流量才会减少。