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在 COVID-19 大流行期间,对透明质酸填充剂注射具有良好的耐受性。

Good tolerance of hyaluronic acid filler injections during the COVID-19 pandemic.

机构信息

Esthétique et Laser de Nogent sur Marne, Centre de Dermatologie, Nogent sur Marne, France.

Esthétique et Laser de Toulouse, Centre de Dermatologie, Toulouse, France.

出版信息

J Cosmet Dermatol. 2023 Feb;22(2):342-346. doi: 10.1111/jocd.15482. Epub 2022 Oct 31.

Abstract

BACKGROUND

The aim of our study was to identify and evaluate the complications related to hyaluronic acid during the COVID-19 pandemic.

METHOD

Twelve dermatologists participated in this study. A cohort and a non-cohort follow-up were ensured.

RESULTS

(1) Cohort follow-up: 1041 patients. 8% had a COVID-19 infection, 27% had received COVID-19 vaccination. 2% had immediate side effects (edema, erythema, bruising). 0.5% had delayed side effects (two inflammatory nodules, one nodule without inflammation, one edema). None of these side effects occurred in the context of infection or COVID-19 vaccinations. (2) Non-cohort follow-up: 7900 syringes used. Two early side effects (inflammatory edema) were reported, of which one occurred 15 days after vaccination. Two cases of delayed side effects such as inflammation on the injected area and inflammatory nodules occurred of which one was in the context of vaccination and one during COVID-19 infection. We estimate the frequency of complications possibly attributable to the disease or to the COVID vaccination to be 0.06% in our population.

DISCUSSION

Complications of HA injections in the context of COVID-19 disease or vaccination appear to be very rare but the frequency could be underestimated because of the low rate of vaccination/infection in our population. Our study shows a very good tolerance of hyaluronic acid injections during the COVID-19 pandemic.

摘要

背景

本研究旨在确定并评估 COVID-19 大流行期间与透明质酸相关的并发症。

方法

12 名皮肤科医生参与了这项研究。我们进行了队列和非队列随访。

结果

(1)队列随访:共 1041 例患者。8%的患者感染了 COVID-19,27%的患者接种了 COVID-19 疫苗。2%的患者出现即刻不良反应(水肿、红斑、瘀斑)。0.5%的患者出现迟发性不良反应(2 例炎性结节,1 例无炎症结节,1 例水肿)。这些不良反应均未在感染或 COVID-19 疫苗接种时发生。(2)非队列随访:共使用了 7900 支注射器。报告了 2 例早期不良反应(炎性水肿),其中 1 例发生在接种疫苗后 15 天。2 例迟发性不良反应,如注射部位炎症和炎性结节,其中 1 例发生在接种疫苗时,1 例发生在 COVID-19 感染时。我们估计,在我们的人群中,可能与疾病或 COVID 疫苗接种相关的并发症的发生率为 0.06%。

讨论

COVID-19 疾病或疫苗接种背景下的 HA 注射并发症似乎非常罕见,但由于我们人群中的疫苗接种/感染率较低,其频率可能被低估。我们的研究表明,在 COVID-19 大流行期间,透明质酸注射具有很好的耐受性。

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