State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Collaborative Innovation Center for Guangxi Ethnic Medicine School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, P. R. China.
School of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing, 210044, Jiangsu, P. R. China.
Chemistry. 2023 Feb 7;29(8):e202203196. doi: 10.1002/chem.202203196. Epub 2022 Dec 19.
As promising photonic material, phototheranostics can be activated in the laser irradiation range of tumor with sensitivity and spatiotemporal precision. However, it is difficult to completely eradicate solid tumors due to their irregularity and limited laser irradiation area. Herein, multi-stimulus responsive HA-Ce6@SWNHs were constructed with single-walled carbon nanohorns (SWNHs) and chlorine e6 (Ce6) modified hyaluronic acid (HA) via non-covalent binding. This SWNHs-based phototheranostics not only exhibited water dispersion but also could target tumor and be activated by near-infrared light for photodynamic therapy (PDT) and photothermal therapy (PTT). Additionally, HA-Ce6@SWNHs could be degraded by hyaluronidase in residual tumor cells, causing HA-Ce6 to fall off the SWNHs surfaces to restore autofluorescence, thus precisely guiding the programmed photodynamic treatments for residual tumor cells after the initial phototherapy. Thus, this work provides a rationally designed multiple-stimulus-response strategy to develop smart SWNHs-based phototheranostics for precise PDT/PTT and post-treatment imaging-guided PDT of residual tumor cells.
作为有前途的光子材料，光热疗可以在肿瘤的激光照射范围内被激活，具有敏感性和时空精度。然而，由于其不规则性和有限的激光照射面积，很难完全根除实体瘤。在此，通过非共价键合，用氯 e6（Ce6）修饰的透明质酸（HA）和单壁碳纳米管（SWNHs）构建了多刺激响应的 HA-Ce6@SWNHs。这种基于 SWNHs 的光热疗不仅表现出水分散性，还可以通过近红外光激活，进行光动力疗法（PDT）和光热疗法（PTT）。此外，HA-Ce6@SWNHs 可以被残留肿瘤细胞中的透明质酸酶降解，导致 HA-Ce6 从 SWNHs 表面脱落，恢复自发荧光，从而精确指导初始光疗后残留肿瘤细胞的程序性光动力治疗。因此，这项工作提供了一种合理设计的多刺激响应策略，用于开发基于智能 SWNHs 的光热疗，以实现精确的 PDT/PTT 以及残留肿瘤细胞的治疗后成像引导 PDT。
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