University of Southern Santa Catarina, Palhoça, Santa Catarina, Brazil.
Child Neurology Department of University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Clin Neurol Neurosurg. 2022 Dec;223:107505. doi: 10.1016/j.clineuro.2022.107505. Epub 2022 Nov 1.
Ischemic stroke is a remarkable cause of death and disability worldwide. Post-stroke depression (PSD) is the most common psychiatric disturbance after stroke. Despite PSD being a potentially treatable condition, it still requires approaches to improve the early diagnosis. The present study aims to investigate the factors associated and correlated variables associated with PSD during hospitalization.
A retrospective cross-sectional study was conducted in a specialized center of neurology in Santa Catarina, Brazil. 148 patients with acute ischemic stroke hospitalized between January 2020 and February 2021 were included. Sociodemographic, clinical and radiological variables were assessed during hospitalization. The Hospital Anxiety and Depression Scale (HADS) was applied, as well as the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Factors associated were investigated through binary logistic regression and continuous variables through correlation tests.
The prevalence of PSD during hospitalization was 31.1%. Factors associated with PSD in the acute phase of the stroke were female sex (OR: 2.6; CI 95%: 1.3-5.4; p < 0.01) and post-stroke anxiety during hospitalization (OR: 4.9; CI 95%: 2.3-10.3; p < 0.01). The variables NIHSS, mRS, and stroke area were positively correlated with HADS - depression values.
This research evidenced a high prevalence of PSD in the acute phase of stroke. Despite the study being conducted during the COVID-19 pandemic, the frequency is similar to the non-pandemic periods. The research provided clues to identify and timely treat patients at greater risk of developing PSD during hospitalization.
缺血性脑卒中是全球范围内显著的死亡和残疾原因。卒中后抑郁（PSD）是卒中后最常见的精神障碍。尽管 PSD 是一种潜在可治疗的疾病，但仍需要采取措施改善早期诊断。本研究旨在探讨与住院期间 PSD 相关的因素和相关变量。
本研究是在巴西圣卡塔琳娜州的一个专门的神经病学中心进行的回顾性横断面研究。共纳入了 2020 年 1 月至 2021 年 2 月期间住院的 148 例急性缺血性脑卒中患者。在住院期间评估了社会人口学、临床和影像学变量。应用医院焦虑抑郁量表（HADS），以及国立卫生研究院卒中量表（NIHSS）和改良 Rankin 量表（mRS）。通过二项逻辑回归分析和相关检验对相关因素和连续变量进行了分析。
住院期间 PSD 的患病率为 31.1%。与卒中急性期 PSD 相关的因素为女性（OR：2.6；95%CI：1.3-5.4；p<0.01）和住院期间卒中后焦虑（OR：4.9；95%CI：2.3-10.3；p<0.01）。NIHSS、mRS 和卒中面积与 HADS 抑郁值呈正相关。
本研究表明卒中急性期 PSD 的患病率较高。尽管研究是在 COVID-19 大流行期间进行的，但频率与非大流行期间相似。该研究为识别和及时治疗住院期间发生 PSD 风险较高的患者提供了线索。
