光学相干断层扫描血管造影术作为脓毒症中终末器官复苏的替代标志物：一项综述。

Optical coherence tomography angiography as a surrogate marker for end-organ resuscitation in sepsis: A review.

作者信息

Courtie Ella, Gilani Ahmed, Veenith Tonny, Blanch Richard J

机构信息

Neuroscience and Ophthalmology Research Group, University of Birmingham, Birmingham, United Kingdom.

Department of Ophthalmology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.

出版信息

Front Med (Lausanne). 2022 Oct 20;9:1023062. doi: 10.3389/fmed.2022.1023062. eCollection 2022.

DOI:10.3389/fmed.2022.1023062

PMID:36341253

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9630739/

Abstract

Sepsis is a severe illness which results in alterations in the end organ microvascular haemodynamics and is associated with a high risk of mortality. There is currently no real-time method of monitoring microcirculatory perfusion during sepsis. Retinal microcirculation is closely linked to cerebral perfusion and may reflect systemic vascular alterations. Retinal perfusion can be assessed using the non-invasive imaging technique of optical coherence tomography angiography (OCTA). This narrative review aims to discuss the utility of using retinal imaging and OCTA in systemic illness and sepsis. OCTA can be used as a functional, non-invasive and real-time biomarker along with other haemodynamic parameters for assessing and managing patients with sepsis.

摘要

脓毒症是一种严重疾病，可导致终末器官微血管血流动力学改变，并伴有高死亡风险。目前尚无在脓毒症期间监测微循环灌注的实时方法。视网膜微循环与脑灌注密切相关，可能反映全身血管改变。可使用光学相干断层扫描血管造影（OCTA）这种非侵入性成像技术评估视网膜灌注。本叙述性综述旨在探讨视网膜成像和OCTA在全身性疾病和脓毒症中的应用。OCTA可作为一种功能性、非侵入性和实时生物标志物，与其他血流动力学参数一起用于评估和管理脓毒症患者。