NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou Gansu, China.
Department of Pathology, Hexi University affiliated Zhangye People's Hospital, Zhangye Gansu, China.
Cancer Control. 2022 Jan-Dec;29:10732748221134398. doi: 10.1177/10732748221134398.
This study aimed to evaluate the expression levels of Shh, Gli1, and Cyr61 proteins in gastric cancer tissues and analyze the relationship between these three proteins and the clinicopathological factors and prognosis of patients.
This was a retrospective study. Four hundred gastric cancer tissue specimens from patients who underwent radical gastrectomy in Zhangye People's Hospital affiliated to Hexi University between February 2013 and February 2021 underwent immunohistochemical analysis.
The positive expression rates of Shh, Gli1, and Cyr61 in gastric cancer tissues were 55.5%, 56.5%, and 64.5%, respectively. The expressions of Shh, Gli1, and Cyr61 in gastric cancer tissues were significantly correlated with tumor size, depth of invasion, and degree of differentiation (P < .05). The expression of Shh protein was positively correlated with the expression of Gli1 protein (P < .01), and the expression of Gli1 protein was positively correlated with the expression of Cyr61 protein (P < .01). Univariate and multivariate analyses showed that the expression of Shh, Gli1, and Cyr61 could predict the prognosis of patients (P < .05). Receiver operating characteristic curve analysis combined with TNM staging could better predict the three-year overall survival of patients (P < .05).
Shh, Gli1, and Cyr61 proteins are significantly expressed in gastric cancer tissues and are risk factors for the prognosis of patients with gastric cancer.
本研究旨在评估 Shh、Gli1 和 Cyr61 蛋白在胃癌组织中的表达水平，并分析这三种蛋白与患者临床病理因素和预后的关系。
这是一项回顾性研究。收集 2013 年 2 月至 2021 年 2 月河西学院附属张掖人民医院行根治性胃切除术的 400 例胃癌组织标本，采用免疫组化法进行分析。
胃癌组织中 Shh、Gli1 和 Cyr61 的阳性表达率分别为 55.5%、56.5%和 64.5%。Shh、Gli1 和 Cyr61 在胃癌组织中的表达与肿瘤大小、浸润深度和分化程度显著相关（P<0.05）。Shh 蛋白的表达与 Gli1 蛋白的表达呈正相关（P<0.01），Gli1 蛋白的表达与 Cyr61 蛋白的表达呈正相关（P<0.01）。单因素和多因素分析表明，Shh、Gli1 和 Cyr61 的表达可预测患者的预后（P<0.05）。ROC 曲线分析联合 TNM 分期可更好地预测患者的 3 年总生存率（P<0.05）。
Shh、Gli1 和 Cyr61 蛋白在胃癌组织中显著表达，是胃癌患者预后的危险因素。
