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变异流感:连接缺失的点。

Variant influenza: connecting the missing dots.

机构信息

Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad, India.

Department of Pharmaceutical Sciences, Faculty of Science and Engineering, Dibrugarh University, Dibrugarh, India.

出版信息

Expert Rev Anti Infect Ther. 2022 Dec;20(12):1567-1585. doi: 10.1080/14787210.2022.2144231. Epub 2022 Nov 18.

Abstract

BACKGROUND

In June 2009, the World Health Organization declared a new pandemic, the 2009 swine influenza pandemic (swine flu). The symptoms of the swine flu pandemic causing strain were comparable to most of the symptoms noted by seasonal influenza.

AREA COVERED

Zoonotic viruses that caused the swine flu pandemic and its preventive measures.

EXPERT OPINION

As per Centers for Disease Control and Prevention (CDC), the clinical manifestations in humans produced by the 2009 H1N1 'swine flu' virus were equivalent to the manifestations caused by related flu strains. The H1N1 vaccination was the most successful prophylactic measure since it prevented the virus from spreading and reduced the intensity and consequences of the pandemic. Despite the availability of therapeutics, the ongoing evolution and appearance of new strains have made it difficult to develop effective vaccines and therapies. Currently, the CDC recommends yearly flu immunization for those aged 6 months and above. The lessons learned from the A/2009/H1N1 pandemic in 2009 indicated that readiness of mankind toward new illnesses caused by mutant viral subtypes that leap from animals to people must be maintained.

摘要

背景

2009 年 6 月,世界卫生组织宣布了一种新的大流行疾病,即 2009 年猪流感大流行(猪流感)。导致猪流感大流行的毒株的症状与季节性流感所记录的大多数症状相似。

涉及领域

引发猪流感大流行及其预防措施的人畜共患病毒。

专家意见

根据疾病控制与预防中心(CDC)的说法,人类中由 2009 年 H1N1“猪流感”病毒引起的临床表现与相关流感株引起的临床表现相当。H1N1 疫苗接种是最成功的预防措施,因为它阻止了病毒的传播,并降低了大流行的强度和后果。尽管有治疗方法,但病毒的不断进化和新毒株的出现使得开发有效的疫苗和疗法变得困难。目前,疾病控制与预防中心建议 6 个月及以上的人群每年进行流感免疫接种。从 2009 年的 A/2009/H1N1 大流行中吸取的经验教训表明,人类必须保持对新疾病的准备,这些新疾病是由从动物传播到人类的突变病毒亚型引起的。

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