Bissig Hugo, Büker Oliver, Stolt Krister, Graham Emmelyn, Wales Leslie, Furtado Andreia, Moura Sara, Metaxiotou Zoe, Lee Seok Hwan, Kartmann Sabrina, Groenesteijn Jarno, Lötters Joost C
Laboratory of Fluid Flow & Volume, NQIS/EIM Sindos, Thessaloniki, Greece.
RISE Research Institutes of Sweden Borås, Sweden.
Biomed Tech (Berl). 2022 Nov 10;68(1):39-50. doi: 10.1515/bmt-2022-0039. Print 2023 Feb 23.
Microfluidic devices are becoming increasingly important in various fields of pharmacy, flow chemistry and healthcare. In the embedded microchannel, the flow rates, the dynamic viscosity of the transported liquids and the fluid dynamic properties play an important role. Various functional auxiliary components of microfluidic devices such as flow restrictors, valves and flow meters need to be characterised with liquids used in several microfluidic applications. However, calibration with water does not always reflect the behaviour of the liquids used in the different applications. Therefore, several National Metrology Institutes (NMI) have developed micro-pipe viscometers for traceable inline measurement of the dynamic viscosity of liquids used in flow applications as part of the EMPIR 18HLT08 MeDDII project. These micro-pipe viscometers allow the calibration of any flow device at different flow rates and the calibration of the dynamic viscosity of the liquid or liquid mixture used under actual flow conditions. The validation of the micro-pipe viscometers has been performed either with traceable reference oils or with different liquids typically administered in hospitals, such as saline and/or glucose solutions or even glycerol-water mixtures for higher dynamic viscosities. Furthermore, measurement results of a commercially available device and a technology demonstrator for the inline measurement of dynamic viscosity and density are presented in this paper.
微流控装置在药学、流动化学和医疗保健等各个领域正变得越来越重要。在嵌入式微通道中，流速、输送液体的动态粘度和流体动力学特性起着重要作用。微流控装置的各种功能辅助部件，如限流器、阀门和流量计，需要用几种微流控应用中使用的液体进行表征。然而，用水校准并不总是能反映不同应用中所使用液体的行为。因此，作为EMPIR 18HLT08 MeDDII项目的一部分，几家国家计量机构（NMI）开发了微管粘度计，用于对流动应用中使用的液体的动态粘度进行可溯源的在线测量。这些微管粘度计能够在不同流速下对任何流动装置进行校准，并能在实际流动条件下对所使用的液体或液体混合物的动态粘度进行校准。微管粘度计的验证工作已通过可溯源的参考油或医院通常使用的不同液体来进行，如盐水和/或葡萄糖溶液，甚至对于更高动态粘度的甘油 - 水混合物。此外，本文还给出了一种用于动态粘度和密度在线测量的商用装置和技术演示器的测量结果。
