Kotian Pravin L, Wu Minwan, Ghosh Ajit, Polach Kevin J, El-Kattan Yahya, Kumar V Satish, Lin Tsu-Hsing, Cheng Xiaogang, Bantia Shanta, Raman Krishnan, Chand Pooran, Babu Yarlagadda S
BioCryst Pharmaceuticals, Inc, 2100 Riverchase Center, Building 200, Suite 200, Birmingham, AL, 35244, USA.
Nucleosides Nucleotides Nucleic Acids. 2023;42(4):317-327. doi: 10.1080/15257770.2022.2142609. Epub 2022 Nov 10.
As a part of our ongoing discovery efforts exploring azasugar as agents for treating various unmet medical needs, we prepared analogs of azasugar as potential anti-hepatitis C virus (HCV) agents. Herein we describe the synthesis of novel 2'β-C-Me 9-deazanucleoside azasugar analogs.