Department of Neurosurgery, Shimane University Faculty of Medicine, Shimane, Japan.
Department of Neurosurgery, Shimane Prefectural Central Hospital, Shimane, Japan; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Clin Neurol Neurosurg. 2022 Dec;223:107497. doi: 10.1016/j.clineuro.2022.107497. Epub 2022 Nov 2.
In elderly populations, the enlargement of the perivascular space is related to small vessel disease and the glymphatic system. Enlarged perivascular spaces (EPVS) in the basal ganglia (EPVS-BG) and EPVS in the centrum semiovale (EPVS-CSO) are associated with different pathophysiological processes. However, the prevalence of EPVS and the factors associated with EPVS location in healthy middle-aged individuals are still unclear. We aimed to determine the prevalence of EPVS and the factors associated with EPVS location among healthy individuals in their 40 s METHODS: This study included 5000 consecutive healthy individuals who underwent screening for brain diseases in Japan from August to December 2018. Of them, the data of individuals in their 40 s were extracted and analyzed. The associations of age, sex, body mass index, smoking and drinking history, and medical history with EPVS location were investigated. Similar analyses were performed for the other age groups. A literature review on the factors associated with EPVS location was also performed.
A total of 1720 individuals in their 40 s were finally included. The prevalence of EPVS-BG and EPVS-CSO was 7.7% and 9.2%, respectively. Age (years), smoking history, and hypertension were associated with EPVS-BG; none of the studied factors were found to be associated with EPVS-CSO. In the elderly, the factors previously reported to be associated with EPVS-BG included atherosclerosis change, while the factors associated with EPVS-CSO were cerebral amyloid angiopathy-related formation.
Both EPVS-BG and EPVS-CSO occurred among healthy individuals in their 40 s, but they did so rarely, and less prevalently than in older age groups. EPVS-BG and EPVS-CSO may represent early imaging signs of the atherosclerotic and cerebral amyloid angiopathy processes, respectively.
The anonymized data for this study will be shared upon any qualified investigator's request to the corresponding author. Primary data from this study will be made available upon reasonable request in accordance with the review board of the research institute.
在老年人群中，血管周围间隙的扩大与小血管疾病和糖液系统有关。基底节区的扩大血管周围间隙（EPVS-BG）和半卵圆中心的扩大血管周围间隙（EPVS-CSO）与不同的病理生理过程有关。然而，健康中年个体中 EPVS 的患病率以及与 EPVS 位置相关的因素仍不清楚。我们旨在确定健康个体中 EPVS 的患病率以及与 EPVS 位置相关的因素。
本研究纳入了 2018 年 8 月至 12 月期间在日本接受脑部疾病筛查的 5000 例连续健康个体。从中提取并分析了 40 多岁个体的数据。研究了年龄、性别、体重指数、吸烟和饮酒史以及既往病史与 EPVS 位置的关系。对其他年龄组也进行了类似的分析。还对与 EPVS 位置相关的因素进行了文献回顾。
最终纳入了 1720 名 40 多岁的个体。BG 和 CSO 的 EPVS 患病率分别为 7.7%和 9.2%。年龄（岁）、吸烟史和高血压与 EPVS-BG 相关；研究的因素均与 EPVS-CSO 无关。在老年人中，先前报道与 EPVS-BG 相关的因素包括动脉粥样硬化改变，而与 EPVS-CSO 相关的因素是与脑淀粉样血管病相关的形成。
40 多岁的健康个体中存在 EPVS-BG 和 EPVS-CSO，但罕见且患病率低于老年人群。EPVS-BG 和 EPVS-CSO 可能分别代表动脉粥样硬化和脑淀粉样血管病过程的早期影像学征象。
本研究的匿名数据将根据研究机构审查委员会的规定，应合格调查员的要求提供给他们。本研究的原始数据将根据合理要求提供给研究人员。
