State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou, 225004, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi, Jiangsu, 214122, China.
Neuropharmacology. 2023 Feb 15;224:109315. doi: 10.1016/j.neuropharm.2022.109315. Epub 2022 Nov 8.
Anorexia nervosa (AN) is a psychiatric disorder characterised by malnutrition, fear of weight gain, and body image disturbances. The aetiology of AN is complex, and may involve environmental factors, genetic factors, and biochemical factors, with the latter meaning that AN may be closely associated with neurons, neurotransmitters, and hormones related to appetite and emotional regulation. In addition, an increasing number of studies have shown there is a link between the intestinal microbiota and psychiatric disorders, such as depression. However, few studies and reviews have focused on AN and gut microbes. Accordingly, in this review, we examine the potential pathogenesis of AN in terms of changes in the gut microbiota and its metabolites, and their effects on AN. The neurobiological function of the nervous system in relation to AN are also been mentioned. Furthermore, we suggest future research directions for this field, and note that probiotics may be developed for use as dietary supplements to help alleviate AN in patients.
神经性厌食症（AN）是一种以营养不良、害怕体重增加和身体形象障碍为特征的精神疾病。AN 的病因复杂，可能涉及环境因素、遗传因素和生化因素，后者意味着 AN 可能与食欲和情绪调节相关的神经元、神经递质和激素密切相关。此外，越来越多的研究表明，肠道微生物群与抑郁症等精神疾病之间存在联系。然而，很少有研究和综述关注 AN 和肠道微生物。因此，在本综述中，我们从肠道微生物及其代谢物的变化以及它们对 AN 的影响方面来探讨 AN 的潜在发病机制。还提到了与 AN 相关的神经系统的神经生物学功能。此外，我们为该领域提出了未来的研究方向，并指出益生菌可能被开发为膳食补充剂，以帮助缓解患者的 AN。
