Lei Bo, Kang Bilin, Lin Wantong, Chen Haichao, Hao Yuejun, Ma Jian, Shi Songhai, Zhong Yi
School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.
McGovern Institute of Brain Research, Beijing 100084, P.R. China.
Sci Adv. 2022 Nov 11;8(45):eabn2136. doi: 10.1126/sciadv.abn2136.
Achieving optimal behavior requires animals to flexibly retrieve prior knowledge. Here, we show that adult newborn granule cells (anbGCs) mediate emotional state-dependent adaptability of memory retrieval. We find that acute social reward (aSR) enhances memory retrieval by increasing the reactivation of engram cells, while acute social stress (aSS) weakens retrieval and reduces the reactivation. Such bidirectional regulation relies on the activation of distinct populations of anbGCs by aSR and aSS, triggering opposing modifications of dDG activity, which is sufficient to regulate and predict the performance of memory retrieval. Concordantly, in emotional disorder models, aSR-dependent memory adaptability is impaired, while the effect of aSS remains intact. Together, our data revealed that anbGCs mediate adaptability of memory retrieval, allowing animals to flexibly retrieve memory according to the current emotional state, and suggested the essential roles of anbGCs in translating emotional information to the regulation of memory expression.
要实现最佳行为，动物需要灵活地检索先前的知识。在这里，我们表明成年新生颗粒细胞（anbGCs）介导记忆检索的情绪状态依赖性适应性。我们发现急性社交奖励（aSR）通过增加记忆印迹细胞的再激活来增强记忆检索，而急性社交压力（aSS）则会削弱检索并减少再激活。这种双向调节依赖于aSR和aSS对不同群体的anbGCs的激活，触发背侧齿状回（dDG）活动的相反变化，这足以调节和预测记忆检索的表现。一致地，在情绪障碍模型中，aSR依赖的记忆适应性受损，而aSS的作用保持不变。总之，我们的数据表明anbGCs介导记忆检索的适应性，使动物能够根据当前情绪状态灵活地检索记忆，并表明anbGCs在将情绪信息转化为记忆表达调节中的重要作用。
