Yee Alicia K, Siriwardhana Leon S, Nixon Gillian M, Walter Lisa M, Wong Flora Y, Horne Rosemary S C
Department of Pediatrics, Monash University, Melbourne, Australia.
Department of Pediatrics, Monash University, Melbourne, Australia; Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, Australia.
J Pediatr. 2023 Apr;255:112-120.e3. doi: 10.1016/j.jpeds.2022.10.035. Epub 2022 Nov 10.
To investigate the amount of time spent in periodic breathing and its consequences in infants born preterm before and after hospital discharge.
Infants born preterm between 28-32 weeks of gestational age were studied during daytime sleep in the supine position at 32-36 weeks of postmenstrual age (PMA), 36-40 weeks of PMA, and 3 months and 6 months of corrected age. The percentage of total sleep time spent in periodic breathing (% total sleep time periodic breathing) was calculated and infants were grouped into below and above the median (8.5% total sleep time periodic breathing) at 32-36 weeks and compared with 36-40 weeks, 3 and 6 months.
Percent total sleep time periodic breathing was not different between 32-36 weeks of PMA (8.5%; 1.5, 15.0) (median, IQR) and 36-40 weeks of PMA (6.6%; 0.9, 15.1) but decreased at 3 (0.4%; 0.0, 2.0) and 6 months of corrected age 0% (0.0, 1.1). Infants who spent above the median % total sleep time periodic breathing at 32-36 weeks of PMA spent more % total sleep time periodic breathing at 36-40 weeks of PMA (18.1%; 7.7, 23.9 vs 2.1%; 0.6, 6.4) and 6 months of corrected age 0.9% (0.0, 3.3) vs 0.0% (0.0, 0.0).
Percentage sleep time spent in periodic breathing did not decrease as infants born preterm approached term corrected age, when they were to be discharged home. High amounts of periodic breathing at 32-36 weeks of PMA was associated with high amounts of periodic breathing at term corrected age (36-40 weeks of PMA), and persistence of periodic breathing at 6 months of corrected age.
研究孕周28 - 32周的早产婴儿出院前后周期性呼吸的时长及其影响。
对孕周28 - 32周的早产婴儿在孕龄（PMA）32 - 36周、36 - 40周、矫正年龄3个月和6个月时仰卧位白天睡眠期间进行研究。计算周期性呼吸占总睡眠时间的百分比（%总睡眠时间周期性呼吸），并将婴儿在32 - 36周时分为低于和高于中位数（8.5%总睡眠时间周期性呼吸）两组，与36 - 40周、3个月和6个月时进行比较。
孕龄32 - 36周时%总睡眠时间周期性呼吸（8.5%；1.5，15.0）（中位数，四分位间距）与孕龄36 - 40周时（6.6%；0.9，15.1）无差异，但在矫正年龄3个月时（0.4%；0.0，2.0）和6个月时（0%；0.0，1.1）下降。孕龄32 - 36周时%总睡眠时间周期性呼吸高于中位数的婴儿在孕龄36 - 40周时%总睡眠时间周期性呼吸更多（18.1%；7.7，23.9对比2.1%；0.6，6.4），在矫正年龄6个月时为0.9%（0.0，3.3）对比0.0%（0.0，0.0）。
早产婴儿接近足月矫正年龄（即准备出院时），周期性呼吸的睡眠时间百分比并未降低。孕龄32 - 36周时大量的周期性呼吸与足月矫正年龄（孕龄36 - 40周）时大量的周期性呼吸以及矫正年龄6个月时周期性呼吸的持续存在有关。
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