镍催化芳基碘化物与1个大气压一氧化碳的氨羰基化反应
Nickel-Catalyzed Aminocarbonylation of Aryl Iodides with 1 atm CO.
作者信息
Liu Ning, Wu Xianqing, Qu Jingping, Chen Yifeng
机构信息
Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science& Technology, 130 Meilong Road, Shanghai, 200237, P. R. China.
出版信息
Chem Asian J. 2023 Jan 3;18(1):e202201061. doi: 10.1002/asia.202201061. Epub 2022 Nov 24.
Reported here is a nickel-catalyzed aminocarbonylation of aromatic iodides with (hetero)aryl anilines and alkyl amines under atmospheric CO pressure. The reaction features with broad substrate scope with excellent functional group tolerance, providing an expedient method for the construction of amide analogues. Notably, amino alcohols can be selectively transformed into the corresponding amides successfully without interfering the hydroxyl group under the current standard conditions.
本文报道了在常压CO压力下，镍催化芳基碘化物与（杂）芳基苯胺和烷基胺的氨羰基化反应。该反应具有底物范围广、官能团耐受性优异的特点，为酰胺类似物的构建提供了一种便捷方法。值得注意的是，在当前标准条件下，氨基醇可以成功地选择性转化为相应的酰胺，而不会干扰羟基。
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