老年人使用涡轮自旋回波序列获得的神经黑色素敏感 MRI 信号的正常值。
Normative Values of Neuromelanin-Sensitive MRI Signal in Older Adults Obtained Using a Turbo Spin Echo Sequence.
机构信息
The Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.
McGill University Research Centre for Studies in Aging, Montreal, Quebec, Canada.
出版信息
J Magn Reson Imaging. 2023 Jul;58(1):294-300. doi: 10.1002/jmri.28530. Epub 2022 Nov 14.
BACKGROUND
The integrity and function of catecholamine neurotransmitter systems can be assessed using neuromelanin-sensitive MRI (NM-MRI). The relevance of this method to neurodegenerative and psychiatric disorders is becoming increasingly evident, and it has potential as a clinical biomarker.
PURPOSE
To support future application of NM-MRI as a clinical biomarker by defining the normative range of NM-MRI signal and volume metrics in cognitively normal older adults.
STUDY TYPE
Prospective.
POPULATION
A total of 152 cognitively normal older adults aged 53-86 years old, including 41 participants who had follow-up NM-MRI data collected 9-16 months later.
FIELD STRENGTH/SEQUENCE: A 3.0 T; NM-MRI turbo spin echo and T1-weighted magnetization-prepared rapid acquisition with gradient echo sequences.
ASSESSMENT
NM-MRI images were processed to yield summary measures of volume and signal (contrast-to-noise ratio, CNR) for the substantia nigra (SN) and locus coeruleus (LC) using a recently developed software employing a fully automated algorithm. Change in these metrics over time was also assessed.
STATISTICAL TESTS
Mean and standard deviation of NM-MRI metrics were calculated; change over time was tested for significance using 1-sample t-tests. P values < 0.05 were considered statistically significant.
RESULTS
At baseline SN signal (CNR) was 10.02% (left) and 10.28% (right) and LC signal was 24.71% (left) and 20.42% (right). Baseline SN volume was 576 mm (left) and 540 mm (right) and LC volume was 6.31 mm (left) and 6.30 mm (right). The only NM-MRI metric showing significant change was a decrease in left SN volume (t = -2.57, P = 0.014).
DATA CONCLUSION
We report normative values for NM-MRI signal and volume in the SN and LC of cognitively normal older adults and explore their change over time. These values may help future efforts to use NM-MRI as a clinical biomarker by facilitating identification of patients with extreme NM-MRI values.
TECHNICAL EFFICACY STAGE
背景
儿茶酚胺神经递质系统的完整性和功能可以通过神经黑色素敏感 MRI（NM-MRI）进行评估。该方法与神经退行性和精神疾病的相关性越来越明显，并且有可能成为一种临床生物标志物。
目的
通过定义认知正常的老年人中 NM-MRI 信号和体积指标的正常范围，为 NM-MRI 作为临床生物标志物的未来应用提供支持。
研究类型
前瞻性。
人群
共有 152 名认知正常的老年人，年龄在 53-86 岁之间，其中 41 名参与者在 9-16 个月后进行了随访 NM-MRI 数据采集。
磁场强度/序列：3.0T；NM-MRI 涡轮自旋回波和 T1 加权磁化准备快速获取梯度回波序列。
评估
使用最近开发的软件对 NM-MRI 图像进行处理，该软件采用完全自动化的算法，得出黑质（SN）和蓝斑（LC）的体积和信号（对比噪声比，CNR）的综合指标。还评估了这些指标随时间的变化。
统计检验
计算 NM-MRI 指标的平均值和标准差；使用 1 样本 t 检验检验随时间的变化是否具有统计学意义。P 值<0.05 被认为具有统计学意义。
结果
在基线时，SN 信号（CNR）为 10.02%（左侧）和 10.28%（右侧），LC 信号为 24.71%（左侧）和 20.42%（右侧）。SN 体积基线为 576mm（左侧）和 540mm（右侧），LC 体积为 6.31mm（左侧）和 6.30mm（右侧）。唯一显示明显变化的 NM-MRI 指标是左侧 SN 体积减少（t=-2.57，P=0.014）。
数据结论
我们报告了认知正常老年人中 SN 和 LC 的 NM-MRI 信号和体积的正常值，并探讨了它们随时间的变化。这些值可能有助于未来将 NM-MRI 用作临床生物标志物的努力，通过促进识别具有极端 NM-MRI 值的患者。
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