囊性纤维化：“排毒”的牺牲品？

Cystic fibrosis: a casualty of "detoxification"?

作者信息

Braganza J M

出版信息

Med Hypotheses. 1986 Jun;20(2):233-43. doi: 10.1016/0306-9877(86)90129-5.

Abstract

It is proposed that excessive and/or aberrant function of cytochromes P450, due to a combination of genetic and environmental influences, is the basic defect in cystic fibrosis. Organs that are involved in oxidative detoxification reactions in foetal life are thus at risk: tissue damage is initiated by excessive production of oxygen free radicals which deplete cellular antioxidants and provoke the secretion of mucus.

摘要

有人提出，由于遗传和环境因素的共同影响，细胞色素P450的功能过度和/或异常是囊性纤维化的基本缺陷。因此，在胎儿期参与氧化解毒反应的器官处于危险之中：组织损伤是由过量产生的氧自由基引发的，这些自由基会耗尽细胞内的抗氧化剂并刺激黏液分泌。