Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: "it's a numbers game"-implications for WNT medulloblastoma dose-reduction clinical trials.
作者信息
Gottardo Nicholas G
机构信息
Department of Pediatric and Adolescent Oncology and Hematology, Perth Children's Hospital, Perth, Western Australia, Australia.
Brain Tumor Research Program, Telethon Kid's Cancer Centre, Telethon Kid's Institute, University of Western Australia, Perth, Western Australia, Australia.
出版信息
Acta Neuropathol. 2023 Jan;145(1):145-147. doi: 10.1007/s00401-022-02518-0. Epub 2022 Nov 20.
Abstract
摘要
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Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: "it's a numbers game"-implications for WNT medulloblastoma dose-reduction clinical trials.TP53和OTX2的基因改变表明WNT型髓母细胞瘤复发风险增加：“这是一场数字游戏”——对WNT型髓母细胞瘤剂量减少临床试验的启示。
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