Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Br J Nutr. 2023 Aug 28;130(4):728-736. doi: 10.1017/S0007114522003683. Epub 2022 Nov 21.
We performed a systematic review and dose-response meta-analysis of randomised trials on the effects of olive oil consumption on blood lipids in adults. A systematic search was performed in PubMed, Scopus and Web of Science databases until May 2021. Randomised controlled trials (RCT) evaluating the effect of olive oil intake on serum total cholesterol (TC), TAG, LDL-cholesterol and HDL-cholesterol in adults were included. The mean difference (MD) and 95 % CI were calculated for each 10 g/d increment in olive oil intake using a random-effects model. A total of thirty-four RCT with 1730 participants were included. Each 10 g/d increase in olive oil consumption had minimal effects on blood lipids including TC (MD: 0·79 mg/dl; 95 % CI (-0·08, 1·66); = 57 %; 31, GRADE = low certainty), LDL-cholesterol (MD: 0·04 mg/dl, 95 % CI (-1·01, 0·94); = 80 %; 31, GRADE = very low certainty), HDL-cholesterol (MD: 0·22 mg/dl; 95 % CI (-0·01, 0·45); = 38 %; 33, GRADE = low certainty) and TAG (MD: 0·39 mg/dl; 95 % CI (-0·33, 1·11); = 7 %; 32, GRADE = low certainty). Levels of TC increased slightly with the increase in olive oil consumption up to 30 g/d (MD: 2·76 mg/dl, 95 % CI (0·01, 5·51)) and then appeared to plateau with a slight downward curve. A trivial non-linear dose-dependent increment was seen for HDL-cholesterol, with the greatest increment at 20 g/d (MD: 1·03 mg/dl, 95 % CI (-1·23, 3·29)). Based on existing evidence, olive oil consumption had trivial effects on levels of serum lipids in adults. More large-scale randomized trials are needed to present more reliable results.
我们对橄榄油摄入对成年人血脂影响的随机试验进行了系统回顾和剂量反应荟萃分析。在 2021 年 5 月之前，在 PubMed、Scopus 和 Web of Science 数据库中进行了系统搜索。纳入评估橄榄油摄入对成年人血清总胆固醇（TC）、TAG、LDL-胆固醇和 HDL-胆固醇影响的随机对照试验（RCT）。使用随机效应模型，计算橄榄油摄入量每增加 10 克/天时的平均差异（MD）和 95%置信区间（CI）。共纳入 34 项 RCT，涉及 1730 名参与者。橄榄油摄入量每增加 10 克/天，对血脂的影响很小，包括 TC（MD：0.79mg/dl；95%CI：-0.08，1.66）； = 57%； 31，GRADE = 低确定性），LDL-胆固醇（MD：0.04mg/dl，95%CI：-1.01，0.94）； = 80%； 31，GRADE = 极低确定性），HDL-胆固醇（MD：0.22mg/dl；95%CI：-0.01，0.45）； = 38%； 33，GRADE = 低确定性）和 TAG（MD：0.39mg/dl；95%CI：-0.33，1.11）； = 7%； 32，GRADE = 低确定性）。随着橄榄油摄入量增加到 30 克/天，TC 水平略有升高（MD：2.76mg/dl，95%CI：0.01，5.51），然后似乎呈平台状，略有下降曲线。HDL-胆固醇呈轻微非线性剂量依赖性增加，最大增量在 20 克/天（MD：1.03mg/dl，95%CI：-1.23，3.29）。基于现有证据，橄榄油摄入对成年人血清脂质水平的影响很小。需要更多大规模的随机试验来提供更可靠的结果。
