沙特阿拉伯乳糜泻患者血清铁、血脂和血清肝酶的测定

Estimation of serum iron, serum lipids and serum liver enzymes in celiac disease patients of Saudi Arabia.

作者信息

Ullah Muhammad Ikram, Alsrhani Abdullah, Atif Muhammad, Shaukat Irfan, Hussain Shahid, Ejaz Hasan

机构信息

Muhammad Ikram Ullah, PhD, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf 72388, Saudi Arabia.

Abdullah Alsrhani, PhD, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf 72388, Saudi Arabia.

出版信息

Pak J Med Sci. 2022 Nov-Dec;38(8):2101-2106. doi: 10.12669/pjms.38.8.6237.

DOI:10.12669/pjms.38.8.6237

PMID:36415230

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9676575/

Abstract

OBJECTIVES

To evaluate the serum biochemical levels in celiac disease (CD) patients.

METHODS

It was a cross-sectional study carried out on 70 subjects, including 40 patients with CD and 30 healthy controls. This study was conducted at Jouf University from November, 2020 to October, 2021. The collected blood specimens were used to perform serum iron, serum lipids, liver enzymes, and human tissue transglutaminase IgA antibodies (anti-HTTG). The hematological parameters including hematocrit and MCV were determined to establish the diagnosis of iron deficiency.

RESULTS

Serum iron was significantly lower in patients as compared to the controls. Serum iron, serum HDL, blood hematocrit and MCV were significantly lower in patients than in controls (p = 0.000). Serum levels of liver enzymes (ALT and AST) and serum human tissue transglutaminase antibodies (anti-HTTG) were significantly higher in patients than in controls (p = 0.000). The correlation studies established the negative correlation of anti-HTTG IgA with serum iron (r = -0.991, p = 0.000), hematocrit (r = -0.967, p = 0.000) and MCV (r = -0.946, p = 0.000) in patients.

CONCLUSION

The serum iron was remarkably reduced in CD patients. A negative correlation was found between anti-HTTG IgA and serum iron, while a positive serum iron was correlated with hematocrit and MCV in CD patients.

摘要

目的

评估乳糜泻（CD）患者的血清生化水平。

方法

这是一项横断面研究，对70名受试者进行了研究，其中包括40名CD患者和30名健康对照者。本研究于2020年11月至2021年10月在朱夫大学进行。采集的血液标本用于检测血清铁、血脂、肝酶和人组织转谷氨酰胺酶IgA抗体（抗HTTG）。测定包括血细胞比容和平均红细胞体积在内的血液学参数以确定缺铁诊断。

结果

与对照组相比，患者的血清铁显著降低。患者的血清铁、血清高密度脂蛋白、血细胞比容和平均红细胞体积均显著低于对照组（p = 0.000）。患者的肝酶（ALT和AST）血清水平和血清人组织转谷氨酰胺酶抗体（抗HTTG）显著高于对照组（p = 0.000）。相关性研究确定了患者中抗HTTG IgA与血清铁（r = -0.991，p = 0.000）、血细胞比容（r = -0.967，p = 0.000）和平均红细胞体积（r = -0.946，p = 0.000）呈负相关。