直立不耐受与 Chiari I 型畸形。

Orthostatic Intolerance and Chiari I Malformation.

机构信息

Department of Pediatrics, Division of Adolescent and Young Adult Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

Neurosurg Clin N Am. 2023 Jan;34(1):43-54. doi: 10.1016/j.nec.2022.09.002.

DOI:10.1016/j.nec.2022.09.002

PMID:36424063

Abstract

Individuals with Chiari malformation can present with symptoms of fatigue, lightheadedness, and syncope-the cardinal features of orthostatic intolerance. Similar orthostatic symptoms can complicate the clinical course following Chiari decompression. The presence of orthostatic intolerance in patients with Chiari malformation is not surprising given the location of the major circulatory control centers and their pathways in the brainstem. This article reviews the normal physiologic response to upright posture and the common forms of orthostatic intolerance encountered in clinical practice. The authors describe the relationship between orthostatic intolerance and Chiari malformation and provide suggestions regarding the evaluation and management of these disorders.

摘要

患有 Chiari 畸形的个体可能会出现疲劳、头晕和晕厥等症状，这些都是直立不耐受的主要特征。Chiari 减压后，类似的直立症状可能会使临床病程复杂化。鉴于主要循环控制中心及其在脑干中的通路的位置，Chiari 畸形患者出现直立不耐受并不奇怪。本文回顾了直立姿势的正常生理反应以及临床实践中常见的直立不耐受形式。作者描述了直立不耐受与 Chiari 畸形之间的关系，并就这些疾病的评估和治疗提供了建议。