Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China.
Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Diseases, Yinghua Dong Street, Hepingli, Chao Yang District, Beijing, 100029, China.
Eur Radiol. 2023 Apr;33(4):2279-2288. doi: 10.1007/s00330-022-09248-7. Epub 2022 Nov 23.
Evaluation and follow-up of idiopathic pulmonary fibrosis (IPF) mainly rely on high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). The elastic registration technique can quantitatively assess lung shrinkage. We aimed to investigate the correlation between lung shrinkage and morphological and functional deterioration in IPF.
Patients with IPF who underwent at least two HRCT scans and PFTs were retrospectively included. Elastic registration was performed on the baseline and follow-up HRCTs to obtain deformation maps of the whole lung. Jacobian determinants were calculated from the deformation fields and after logarithm transformation, log_jac values were represented on color maps to describe morphological deterioration, and to assess the correlation between log_jac values and PFTs.
A total of 69 patients with IPF (male 66) were included. Jacobian maps demonstrated constriction of the lung parenchyma marked at the lung base in patients who were deteriorated on visual and PFT assessment. The log_jac values were significantly reduced in the deteriorated patients compared to the stable patients. Mean log_jac values showed positive correlation with baseline percentage of predicted vital capacity (VC%) (r = 0.394, p < 0.05) and percentage of predicted forced vital capacity (FVC%) (r = 0.395, p < 0.05). Additionally, the mean log_jac values were positively correlated with pulmonary vascular volume (r = 0.438, p < 0.01) and the number of pulmonary vascular branches (r = 0.326, p < 0.01).
Elastic registration between baseline and follow-up HRCT was helpful to quantitatively assess the morphological deterioration of lung shrinkage in IPF, and the quantitative indicator log_jac values were significantly correlated with PFTs.
• The elastic registration on HRCT was helpful to quantitatively assess the deterioration of IPF. • Jacobian logarithm was significantly reduced in deteriorated patients and mean log_jac values were correlated with PFTs. • The mean log_jac values were related to the changes of pulmonary vascular volume and the number of vascular branches.
特发性肺纤维化（IPF）的评估和随访主要依赖于高分辨率计算机断层扫描（HRCT）和肺功能测试（PFT）。弹性配准技术可定量评估肺容积缩小。本研究旨在探讨 IPF 中肺容积缩小与形态和功能恶化的相关性。
回顾性纳入至少接受两次 HRCT 扫描和 PFT 的 IPF 患者。在基线和随访 HRCT 上进行弹性配准，以获得整个肺的变形图。从变形场中计算雅可比行列式，并进行对数转换，将 log_jac 值表示在彩色图上，以描述形态恶化，并评估 log_jac 值与 PFT 的相关性。
共纳入 69 例 IPF 患者（男性 66 例）。在视觉和 PFT 评估恶化的患者中，Jacobian 图谱显示肺实质在肺底部收缩。与稳定患者相比，恶化患者的 log_jac 值显著降低。平均 log_jac 值与基线预计肺活量百分比（VC%）呈正相关（r = 0.394，p < 0.05）和预计用力肺活量百分比（FVC%）（r = 0.395，p < 0.05）。此外，平均 log_jac 值与肺血管容积呈正相关（r = 0.438，p < 0.01）和肺血管分支数（r = 0.326，p < 0.01）。
HRCT 基线和随访之间的弹性配准有助于定量评估 IPF 中肺容积缩小的形态恶化，定量指标 log_jac 值与 PFT 显著相关。
HRCT 上的弹性配准有助于定量评估 IPF 的恶化情况。
恶化患者的 Jacobian 对数明显降低，平均 log_jac 值与 PFT 相关。
平均 log_jac 值与肺血管容积和血管分支数的变化有关。
Zotero 插件
