Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Expert Rev Cardiovasc Ther. 2022 Dec;20(12):911-918. doi: 10.1080/14779072.2022.2153118. Epub 2022 Dec 5.
Bioprosthetic aortic valves are increasingly being utilized in a younger population due to improved durability and possibility for future valve-in-valve replacement. This has resulted in a larger population of patients with bioprosthetic aortic valve degeneration requiring re-intervention. Despite no head-to-head comparisons between redo surgical aortic valve replacement (SAVR) and valve-in-valve transcatheter aortic valve replacement (ViV TAVR), observational studies suggest a comparable long-term risk between which led to the incorporation of ViV TAVR to current guidelines.
This article summarizes the comparative performance of redo SAVR versus ViV TAVR in patients with bioprosthetic valve dysfunction and provides a guide to better understand which procedure is best for which patient.
With the rising use of TAVR, we will be confronted with more bioprosthetic aortic valve degeneration requiring re-intervention. Based on the available evidence and expert consensus, we propose that patients with bioprosthetic aortic valve degeneration be treated with ViV TAVR if they have a history of radiation heart disease, prohibitive surgical risk, and multiple sternotomies; while patients with small prostheses, history of infective endocarditis, those at high risk for coronary obstruction, and those with need for other cardiac surgery will be managed with redo SAVR.
由于生物瓣的耐久性提高以及未来可能进行瓣中瓣置换,生物瓣主动脉瓣在较年轻的人群中越来越多地被使用。这导致需要再次介入治疗的生物瓣主动脉瓣退行性病变患者数量增加。尽管 redo 外科主动脉瓣置换术(SAVR)和瓣中瓣经导管主动脉瓣置换术(ViV TAVR)之间没有直接比较,但观察性研究表明,两者的长期风险相当,这导致 ViV TAVR 被纳入当前指南。
本文总结了 redo SAVR 与 ViV TAVR 在生物瓣功能障碍患者中的比较性能,并提供了一个指南,以更好地了解哪种手术最适合哪种患者。
随着 TAVR 的使用增加,我们将面临更多需要再次介入治疗的生物瓣主动脉瓣退行性病变。基于现有证据和专家共识,我们建议,如果患者有放射性心脏病史、手术风险极高、多次开胸手术史,则采用 ViV TAVR 治疗生物瓣主动脉瓣退行性病变;而对于小瓣、感染性心内膜炎病史、冠状动脉阻塞风险高以及需要进行其他心脏手术的患者,则采用 redo SAVR 治疗。