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澳大利亚普通实践中儿科人群精神药物处方率 2000-2016 年。

Rates of psychotropic medicine prescribing in paediatric populations in Australian general practice from 2000-2016.

机构信息

Room 308, Badham Building A16, The University of Sydney, NSW 2006, Australia.

School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

出版信息

Eur Neuropsychopharmacol. 2022 Dec;65:68-78. doi: 10.1016/j.euroneuro.2022.09.007. Epub 2022 Nov 23.

Abstract

General practitioner (GP) prescribing of psychotropic medicines to paediatric patients is increasing across countries, sparking the need for additional research into this field. We examined prescribing rates, GP and patient characteristics and indications associated with prescribing psychotropic medicines to paediatric patients in Australian general practice, using data from the Bettering the Evaluation and Care of Health (BEACH) program. We extracted all encounters with children aged 3 to 17 from 2000 to 2016. Psychotropic medicines were defined as those in the ATC codes N05 (Psycholeptics) and N06 (Psychoanaleptics). Of the 144,397 encounters, GPs prescribed 1829 psychotropic medicines to paediatric patients at an average rate of 1.16 prescriptions per 100 encounters (95% confidence interval 1.09-1.23). We found that the rate of psychotropic medicines prescribed to paediatric patients in Australian general practice increased. Patients who were adolescent, female, socio-economically disadvantaged or from an English-speaking background were significantly more likely to be prescribed a psychotropic medicine. GP practices in remote or regional areas and Australian graduate GPs were more likely to prescribe psychotropic medicines to paediatric patients. Depression, attention deficit hyperactivity disorder, anxiety and autism were the most common psychiatric indications managed with psychotropic medicines. Antidepressants, psychostimulants, benzodiazepines, antipsychotics and other psychotropic medicines were prescribed, signifying a high rate of off-label use. Sertraline was the most common psychotropic medicine prescribed, followed by fluoxetine and methylphenidate. Future studies involving data from other prescribers, e.g. paediatricians and psychiatrists, and studies linking prescribed medicines to their indications may widen our understanding of psychotropic medicine prescribing in Australian paediatric patients.

摘要

全科医生(GP)为儿科患者开具精神药物的处方在各国都有所增加,这促使人们需要对这一领域进行更多的研究。我们使用来自 Bettering the Evaluation and Care of Health(BEACH)计划的数据,研究了澳大利亚全科实践中为儿科患者开具精神药物的处方率、GP 和患者特征以及与开具精神药物相关的指征。我们从 2000 年至 2016 年期间提取了所有 3 至 17 岁儿童的就诊记录。精神药物被定义为 ATC 代码 N05(精神药物)和 N06(精神兴奋药)中的药物。在 144397 次就诊中,GP 为儿科患者开出了 1829 种精神药物,平均每 100 次就诊开出 1.16 种处方(95%置信区间 1.09-1.23)。我们发现,澳大利亚全科实践中为儿科患者开具精神药物的比例有所增加。青少年、女性、社会经济地位较低或来自英语国家背景的患者被开具精神药物的可能性显著增加。偏远或地区性的 GP 实践和澳大利亚毕业的 GP 更有可能为儿科患者开具精神药物。抑郁、注意力缺陷多动障碍、焦虑和自闭症是使用精神药物治疗的最常见精神指征。抗抑郁药、精神兴奋剂、苯二氮䓬类药物、抗精神病药和其他精神药物被开具,表明存在很高的标签外使用。舍曲林是最常开具的精神药物,其次是氟西汀和哌甲酯。涉及其他处方者(如儿科医生和精神科医生)数据的未来研究以及将开出的药物与其指征联系起来的研究可能会扩大我们对澳大利亚儿科患者精神药物处方的理解。

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