Cobb Timothy E, Dimock Richard A C, Memon Sahib D, Consigliere Paolo, Ajami Sam, Imam Mohamed, Narvani A Ali
Conquest Hospital, East Sussex Healthcare NHS Trust, St. Leonards-On-Sea, UK.
The Rowley Bristow Unit, Ashford and St. Peter's NHS Trust, Chertsey, UK.
Arch Bone Jt Surg. 2022 Oct;10(10):833-846. doi: 10.22038/ABJS.2022.61345.3012.
Repair of massive rotator cuff tears remains a challenging process with mixed success. There is a growing interest in the use of patches to augment the repair construct and the potential to enhance the strength, healing, and associated clinical outcomes. Such patches may be synthetic, xenograft, or autograft/allograft, and a variety of techniques have been tried to biologically enhance their integration and performance. The materials used are rapidly advancing, as is our understanding of their effects on rotator cuff tissue. This article aims to evaluate what we currently know about patch augmentation through a comprehensive review of the available literature.
We explore the results of existing clinical trials for each graft type, new manufacturing methods, novel techniques for biological enhancement, and the histological and biomechanical impact of patch augmentation.
There are promising results in short-term studies, which suggest that patch augmentation has great potential to improve the success rate. In particular, this appears to be true for human dermal allograft, while porcine dermal grafts and some synthetic grafts have also had promising results.
However, there remains a need for high-quality, prospective clinical trials directly comparing each type of graft and the effect that they have on the clinical and radiological outcomes of rotator cuff repair.
巨大肩袖撕裂的修复仍然是一个具有挑战性的过程,成功率不一。人们越来越关注使用补片来加强修复结构,并增强其强度、促进愈合以及改善相关临床结果的潜力。此类补片可以是合成材料、异种移植物或自体移植物/同种异体移植物,并且已经尝试了多种技术来从生物学角度增强它们的整合性和性能。所使用的材料在迅速发展,我们对它们对肩袖组织的影响的理解也是如此。本文旨在通过对现有文献的全面综述来评估我们目前对补片增强的了解。
我们探讨了每种移植物类型的现有临床试验结果、新的制造方法、生物学增强的新技术以及补片增强的组织学和生物力学影响。
短期研究取得了有前景的结果,这表明补片增强有很大潜力提高成功率。特别是,人真皮同种异体移植物似乎确实如此,而猪真皮移植物和一些合成移植物也取得了有前景的结果。
然而,仍然需要高质量的前瞻性临床试验,直接比较每种类型的移植物及其对肩袖修复的临床和影像学结果的影响。