[Neurocognitive impairment and characteristics of neurocognitive performance among people with HIV on antiretroviral treatment].

Using two measuring tools to examine the prevalence and correlates of neurocognitive impairment (NCI) as well as characteristics of neurocognitive performance among people with HIV (PWH) on antiretroviral treatment (ART). A total of 2 250 treated PWH from the Comparative HIV and Aging Research in Taizhou (CHART) were recruited in Taizhou, Zhejiang province. The Chinese version of the Mini-mental State Examination (MMSE) and the International HIV Dementia Scale (IHDS) were used to evaluate their neurocognitive performance. Cluster analysis was conducted on the seven cognitive domains in the scale. Among 2 250 treated PWH, 48.0% (1 080/2 250) were aged 45 to 89, 79.2% (1 782/2 250) were male, and 37.8% (852/2 250) had primary school education or below. The prevalence of neurocognitive impairment judged by MMSE and IHDS among HIV-infected people was 14.3% (321/2 250) and 31.8% (716/2 250), respectively. Aged 60 to 89 (a=2.63, 95%:1.52-4.56), depressive symptoms (a=5.58, 95%:4.20-7.40) and treatment with EFV (a=2.86, 95%:1.89-4.34) were main risk factors of NCI diagnosed by MMSE. Male (a=0.71, 95%:0.51-1.00), overweight (a=0.63, 95%:0.44-0.89), and high education level (a=0.11, 95%:0.05-0.25) were protective factors of NCI diagnosed by MMSE. Aged 60 to 89 (a=3.10, 95%:2.09-4.59), depressive symptoms (a=1.78, 95%:1.44-2.20) and treatment with EFV (a=1.79, 95%:1.41-2.29) were risk factors of NCI diagnosed by IHDS. Male (a=0.75, 95%:0.58-0.97), underweight (a=0.67, 95%:0.47-0.96), baseline CD4 T lymphocyte (CD4) counts ≥350 cells/μl (a=0.69, 95%:0.53-0.91) and high education level (a=0.23, 95%:0.14-0.39) were protective factors of NCI diagnosed by IHDS. The neurocognitive performance of HIV-infected people can be divided into four main types. Among four types, age, gender, education level, alcohol drinking, depressive symptoms, waist-to-hip ratio, hypertension, diabetes, baseline CD4 counts and treatment with EFV were different statistically (all <0.05). There are four main types of neurocognitive performance in treated PWH. The prevalence of NCI is high among this population, underscoring the need for tailored prevention and intervention.