Department of Cardiovascular Surgery, Erzurum Regional Education and Research Hospital, Erzurum, Turkey.
Department of Pediatric Cardiovascular Surgery, Erzurum Regional Education and Research Hospital, Erzurum, Turkey.
Braz J Cardiovasc Surg. 2023 Apr 23;38(2):259-264. doi: 10.21470/1678-9741-2022-0093.
Our study aimed to examine the impacts of blood cardioplegia (BC) and del Nido cardioplegia (DNC) solutions - which we used in isolated coronary artery bypass grafting (CABG) - on early mortality and major adverse events (MAE).
We retrospectively analyzed 329 consecutive patients who underwent CABG in our clinic between January 2016 and January 2020. Myocardial infarction, reoperation, cardiac tamponade, stroke, renal failure, extracorporeal membrane oxygenation requirement, and cardiopulmonary resuscitation were defined as MAE. The group in which DNC was used was Group D (181 [55%] patients), and the group in which BC was used was Group B (141 [45%] patients).
No statistically significant difference was determined between the groups regarding age, weight, body surface area, gender, or European System for Cardiac Operative Risk Evaluation score (P=0.615, P=0.560, P=0.934, P=0.365, P=0.955, respectively). Although there was no statistically significant difference between the groups in terms of aortic cross-clamping time (P=0.712), cardiopulmonary bypass duration was longer in Group B (P=0.001). Even though the incidence of stroke was higher in Group B (P=0.030), no statistically significant difference was observed between the groups regarding total incidence of MAE, mortality, mechanical ventilation time, length of stay in the intensive care unit, or length of hospital stay (P=0.153, P=0.130, P=0.689, P=0.710, P=0.613, respectively).
We found no significant difference in MAE, mortality, duration of mechanical ventilation, intensive care unit stay, or hospital stay between the DNC and BC groups. We believe that both solutions can be used safely for cardiac protection in the adult patient population.
本研究旨在探讨我们在体外循环冠状动脉旁路移植术（CABG）中使用的血停搏液（BC）和 Del Nido 停搏液（DNC）溶液对早期死亡率和主要不良事件（MAE）的影响。
我们回顾性分析了 2016 年 1 月至 2020 年 1 月在我院接受 CABG 的 329 例连续患者。心肌梗死、再次手术、心脏压塞、中风、肾衰竭、体外膜氧合需要和心肺复苏定义为 MAE。使用 DNC 的组为 D 组（181 [55%]例），使用 BC 的组为 B 组（141 [45%]例）。
两组在年龄、体重、体表面积、性别或欧洲心脏手术风险评估系统评分方面无统计学差异（P=0.615，P=0.560，P=0.934，P=0.365，P=0.955）。虽然两组的主动脉阻断时间无统计学差异（P=0.712），但 B 组的体外循环时间更长（P=0.001）。虽然 B 组中风发生率较高（P=0.030），但两组 MAE 总发生率、死亡率、机械通气时间、重症监护病房停留时间和住院时间无统计学差异（P=0.153，P=0.130，P=0.689，P=0.710，P=0.613）。
我们发现 DNC 和 BC 组在 MAE、死亡率、机械通气时间、重症监护病房停留时间和住院时间方面无显著差异。我们认为两种溶液均可安全用于成年患者的心脏保护。
