三阴性乳腺癌细胞中的肿瘤细胞异质性影响对顺铂的反应，但不影响对阿霉素的反应。
Tumour cell heterogeneity in triple-negative breast cancer cells affects response to cisplatin, but not doxorubicin.
作者信息
Yaourtis Andria M, Levina Aviva, Lay Peter A
机构信息
School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia; Sydney Analytical, The University of Sydney, Sydney, NSW 2006, Australia.
出版信息
J Inorg Biochem. 2023 Feb;239:112082. doi: 10.1016/j.jinorgbio.2022.112082. Epub 2022 Nov 25.
Tumour cell heterogeneity affects cisplatin but not doxorubicin cytotoxicity in two phenotypes of the triple-negative breast cancer (TNBC) cell line, MDA-MB-231. A mesenchymal MDA-MB-231 phenotype was three times less sensitive to cisplatin than an epithelial-type phenotype from the same cell line, which has important implications in the success of TNBC chemotherapies.
肿瘤细胞异质性影响三阴性乳腺癌（TNBC）细胞系MDA-MB-231两种表型中顺铂的细胞毒性，但不影响阿霉素的细胞毒性。与同一细胞系的上皮型表型相比，间充质MDA-MB-231表型对顺铂的敏感性低三倍，这对TNBC化疗的成功具有重要意义。
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