通过肝靶向递送来递送虾青素，以增强清除自由基的能力并防止线粒体去极化。
Hepatic-targeted delivery of astaxanthin for enhanced scavenging free radical scavenge and preventing mitochondrial depolarization.
机构信息
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, Zhejiang, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan 1, Ganjingzi District, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan 1, Ganjingzi District, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
出版信息
Food Chem. 2023 Apr 16;406:135036. doi: 10.1016/j.foodchem.2022.135036. Epub 2022 Nov 23.
Astaxanthin (AST), as natural hydrophobic nutrition, has exhibited health-promoting benefits for its outstanding antioxidant property. However, most studies tend to enhance its stability and solubility while the targeted delivery of AST is limited. In this study, liver-targeted nanocarriers were designed and prepared by lactobionic acid-modified (2-hydroxypropyl-β-cyclodextrin) for efficient controlled delivery of AST. The minimum average size of AST nanoparticles was about 98 nm with a polydispersity index (PDI) of 0.41. The lactobionic acid-modified AST nanoparticles exhibited significant cellular uptake, and an admirable ability to scavenge free radicals for HO-induced HepaRG cells in preventing mitochondrial depolarization. Moreover, accumulation of AST nanoparticles in liver was observed due to the modification of lactobionic acid (LA) of the nanocarriers through the specific binding of LA-asialoglycoprotein receptors. The results in this study provided a new idea for liver-specific nutrition delivery of AST in developing functional food for liver disease nutrition intervention.
虾青素（AST）作为一种天然疏水性营养物质，因其出色的抗氧化性能而具有促进健康的益处。然而，大多数研究倾向于提高其稳定性和溶解度，而 AST 的靶向递送则受到限制。在本研究中，通过乳酸修饰（2-羟丙基-β-环糊精）设计并制备了肝靶向纳米载体，以有效控制 AST 的递送。AST 纳米颗粒的最小平均粒径约为 98nm，多分散指数（PDI）为 0.41。乳酸修饰的 AST 纳米颗粒表现出明显的细胞摄取能力，并具有清除 HO 诱导的 HepaRG 细胞自由基、防止线粒体去极化的优异能力。此外，由于纳米载体上的乳酸（LA）的修饰，通过 LA- 糖蛋白受体的特异性结合，观察到 AST 纳米颗粒在肝脏中的积累。本研究的结果为开发用于肝病营养干预的功能性食品中 AST 的肝特异性营养递送提供了新的思路。
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