Engen Rachel M, Kirmani Sonya
Department of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin, USA.
Pediatr Transplant. 2023 Feb;27 Suppl 1:e14253. doi: 10.1111/petr.14253. Epub 2022 Dec 5.
Multiorgan transplantation is increasingly common, driving recent increased attention to multiorgan allocation policies.
In this review, we summarize current multiorgan transplant allocation policies in the United States, with attention to recent and proposed changes and their impact on pediatric candidates.
Existing multiorgan transplant policies attempt to balance equity and utility. Currently, there are clear allocation policies for some, but not all, multiorgan transplant combinations, and there are no mandatory outcomes reporting. Multiorgan candidates are prioritized above all kidney-alone transplant candidates, which negatively affect pediatric kidney transplant wait times. Pediatric candidates are typically exempt from multiorgan listing criteria.
Multiorgan transplant allocation presents unique challenges for policy development. As the United States Network for Organ Sharing begins exploring continuous distribution allocation, multiorgan allocation will require special consideration and the development of clear and equitable policies.
多器官移植越来越普遍,这促使近期人们对多器官分配政策的关注度不断提高。
在本综述中,我们总结了美国当前的多器官移植分配政策,关注近期及提议的变化及其对儿科候选者的影响。
现有的多器官移植政策试图平衡公平性和实用性。目前,对于部分而非所有的多器官移植组合有明确的分配政策,且没有强制性的结果报告。多器官候选者的优先级高于所有仅接受肾脏移植的候选者,这对儿科肾脏移植等待时间产生了负面影响。儿科候选者通常免于多器官列入标准。
多器官移植分配在政策制定方面存在独特挑战。随着美国器官共享网络开始探索持续分配方式,多器官分配将需要特别考虑并制定明确且公平的政策。