RNA生物学：可变剪接影响突触功能与行为。
RNA biology: Alternative splicing hits synaptic function and behavior.
作者信息
Kiebler Michael A, Ninkovic Jovica
机构信息
Department of Anatomy and Cell Biology, Biomedical Center Munich (BMC), Faculty of Medicine, LMU, Munich, Germany.
Department of Anatomy and Cell Biology, Biomedical Center Munich (BMC), Faculty of Medicine, LMU, Munich, Germany; Institute of Stem Cell Research, Helmholtz Zentrum Munich, Munich, Germany.
出版信息
Curr Biol. 2022 Dec 5;32(23):R1314-R1316. doi: 10.1016/j.cub.2022.10.060.
A new study finds the spliceosome protein SNRNP70 in cytoplasmic RNA granules in zebrafish motoneurons. Intriguingly, cytoplasmic SNRNP70 is essential for functional neuromuscular junctions, possibly due to a role in alternative splicing of z+agrin mRNA.
一项新研究在斑马鱼运动神经元的细胞质RNA颗粒中发现了剪接体蛋白SNRNP70。有趣的是，细胞质中的SNRNP70对于功能性神经肌肉接头至关重要，这可能是由于它在z+聚集蛋白聚糖（z+agrin）mRNA的可变剪接中发挥了作用。
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