NMDA 抑制剂：一种辅助阿尔茨海默病治疗的潜在手段。

NMDA Inhibitors: A Potential Contrivance to Assist in Management of Alzheimer's Disease.

机构信息

Himalayan Environmental Studies and Conservation Organization (HESCO), Dehradun 248 006, Uttarakhand, India.

Department of Life Sciences, Graphic Era Deemed to be University, Dehradun-248 002, Uttarakhand, India.

出版信息

Comb Chem High Throughput Screen. 2023;26(12):2099-2112. doi: 10.2174/1386207325666220428112541.

DOI:10.2174/1386207325666220428112541

PMID:36476432

Abstract

Alzheimer's disease (AD) is an increasingly common neurodegenerative disease that attracts the attention of researchers and medical community in order to develop new, safe and more effective drugs. Currently available drugs could only slow the AD progression and relieve the symptoms, in addition to being linked to moderate-to-severe side effects. N-methyl D-aspartate (NMDA) receptors antagonists were reported to have the ability to block the glutamate-mediated excitotoxic activity being good therapeutic targets for several neurodegenerative diseases, including AD. Based on data obtained so far, this review provides an overview over the use of NMDA antagonists for AD treatment, starting with a key emphasis on present features and future aspects regarding the use of NMDA antagonists for AD, and lastly a key focus is also given on its use in precision medicine.

摘要

阿尔茨海默病（AD）是一种日益常见的神经退行性疾病，为了开发新的、安全且更有效的药物，引起了研究人员和医学界的关注。目前可用的药物只能减缓 AD 的进展并缓解症状，此外还与中度至重度副作用有关。据报道，N-甲基-D-天冬氨酸（NMDA）受体拮抗剂具有阻断谷氨酸介导的兴奋性毒性作用的能力，是几种神经退行性疾病（包括 AD）的良好治疗靶点。基于迄今为止获得的数据，本综述概述了 NMDA 拮抗剂在 AD 治疗中的应用，首先重点介绍了目前关于 NMDA 拮抗剂在 AD 中的应用的特点和未来方面，最后还重点介绍了其在精准医学中的应用。