Department of Radiology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400030, China.
Department of Breast Cancer Center, Chongqing University Cancer Hospital, Chongqing, China.
Dis Markers. 2022 Nov 28;2022:8270100. doi: 10.1155/2022/8270100. eCollection 2022.
To evaluate the longitudinal changes of brain degree centrality (DC) and functional connectivity (FC) in breast cancer patients after the first cycle of neoadjuvant chemotherapy (NAC).
Thirty-five breast cancer patients were included in the NAC group. Resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological test were performed at baseline before NAC (time point 0, TP0) and after the first cycle of NAC (time point 1, TP1). The healthy controls (HC) included 30 healthy subjects and received the same rs-fMRI scan and neuropsychological test as the above-mentioned NAC group at one time point. DC and FC analyses were conducted to assess brain connectivity of all participants. Receiver operating characteristic (ROC) curve was used to assess the ability of DC and FC in distinguishing patients before and after chemotherapy.
In the NAC group, the Self-Rating Anxiety Scale scores decreased significantly over time. At TP0 and TP1, the Digital Span Test forward score of the NAC group was significantly lower than that of the HC group. In the NAC group, DC in the right middle frontal gyrus and left precentral gyrus/middle frontal gyrus decreased significantly at TP1, and FC between the left precentral gyrus/middle frontal gyrus and bilateral precuneus was significantly reduced at TP1. Through ROC analysis, we found that the area under the curve (AUC) of DC, FC, and the combined model in distinguishing patients in TP0 or TP1 was 0.7886, 0.7665, and 0.8278, respectively.
Brain connectivity, involving executive and motor function related brain areas, changes in the short term after NAC treatment in breast cancer patients.
评估乳腺癌患者新辅助化疗（NAC）第一周期后大脑度中心度（DC）和功能连接（FC）的纵向变化。
纳入 35 例 NAC 组乳腺癌患者。在 NAC 前（时间点 0，TP0）和第一周期 NAC 后（时间点 1，TP1）进行静息态功能磁共振成像（rs-fMRI）和神经心理学测试。健康对照组（HC）包括 30 名健康受试者，在同一时间点接受与上述 NAC 组相同的 rs-fMRI 扫描和神经心理学测试。对所有参与者进行 DC 和 FC 分析以评估大脑连接。使用受试者工作特征（ROC）曲线评估 DC 和 FC 在区分化疗前后患者的能力。
在 NAC 组中，焦虑自评量表评分随时间显著降低。在 TP0 和 TP1，NAC 组数字跨度测试前得分明显低于 HC 组。在 NAC 组中，TP1 时右侧额中回和左侧中央前回/额中回的 DC 显著降低，TP1 时左中央前回/额中回与双侧楔前叶之间的 FC 显著降低。通过 ROC 分析，我们发现 DC、FC 和联合模型在区分 TP0 或 TP1 患者的曲线下面积（AUC）分别为 0.7886、0.7665 和 0.8278。
乳腺癌患者 NAC 治疗后短期大脑连接，涉及执行和运动功能相关脑区，发生变化。
